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清华大学医学院/免疫学研究所/生命联合中心彭敏课题组2019年8月招聘博士后

日期:2019-08-14 来源:清华大学医学院

实验室研究方向:

T cells play essential roles in immune response. We are studying T cells with two directions:

1. Functional genomics in primary T cells

We are applying genome-wide CRISPR/Cas9 screen in primary T cell in vivo to answer fundamental questions in T cell biology, including development, activation, proliferation and differentiation, as well as T cell fitness (e.g. exhaustion) in tumor microenvironment. Identified novel genes and regulatory circuits have been used to design novel therapies for diseases.

2. Mechanisms of metabolic regulation of T cells

Metabolic reprogramming is a hallmark of T cell activation, but how metabolic pathways regulate T cell function remains poorly understood. We are using mouse models with gain- and loss-of-function of key metabolic enzymes to decipher metabolic regulation T cell, and try to target metabolism to treat immune-related diseases.

近期代表性成果如下:

1. Min Peng, Na Yin, Ming O. Li. SZT2 dictates GATOR control of mTORC1 signaling. Nature. 2017 Mar 16;543(7645):433-437.

2. Min Peng*, Na Yin*, Sagar Chhangawala, Ke Xu, Christina S. Leslie, Ming O. Li. Aerobic glycolysis promotes T helper 1 cell differentiation through an epigenetic mechanism. Science, 2016 Oct 28; 354(6311): 481-484. *equal contribution.

Preview in Science, 2016 Oct 28; 354(6311): 419-420. “Warburg meets epigenetics”.

Preview in Dev Cell, 2016 November 7;39: 286-287. “Metabolic Control of Cellular Differentiation”.

Preview in Cell Metab, 2016 November 8; 24: 651-652. “Metabolic Signaling Drives IFN-g”.

3. Min Peng, Na Yin, Ming O. Li. Sestrins Function as Guanine Nucleotide Dissociation Inhibitors for Rag GTPases to Control mTORC1 Signaling. Cell. 2014 Sep 25; 159(1): 122-33.

Highlighted in Nat Rev Mol Cell Biol, 2014; 15: 701, “A RAG dissociation inhibitor”.

博士后 招聘1名:

应聘条件:

1)具有免疫学、分子和细胞生物学相关专业博士学位,获得博士学位1年以内

2)近3年以第一作者身份在国际知名学术期刊发表研究论文,符合清华大学博士后入站标准

3)热爱科研工作,责任心强,具备团队合作精神

4)具备较好的英语沟通、阅读和写作能力

岗位待遇:在清华大学博士后的标准薪酬和待遇基础上,课题组支持博士后申请相应奖学金计划。享受具有竞争力的薪酬资助和优秀的科研环境。具体情况参见清华大学博士后申请相关网页。

申请材料以及申请方式:

1) 个人简历(包括主要学习和研究经历、发表论文列表,参与项目、奖励等)

2) 个人英文陈述(包括详细的个人研究兴趣,主要研究成果和未来的职业规划等)

3) 2-3位推荐人(其中一位应为本人博士导师)的联系方式

4) 申请材料发送至pengmin@tsinghua.edu.cn,主题标明“姓名+应聘博士后+硕博英才网“

原文出处:

http://www.med.tsinghua.edu.cn/SingleServlet?newsId=1764

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