丹麦哥本哈根大学博士后职位---昼夜节律生物学与生物信息学

哥本哈根大学 （英文: University of Copenhagen; 丹麦文: Københavns Universitet；简称：UCPH / KU）坐落于丹麦王国首都哥本哈根，是丹麦最高学府，4EU＋联盟、国际研究型大学联盟、欧洲研究型大学联盟、欧洲首都大学联盟、欧洲大学协会成员。大学建于1479年，已有500多年历史，从最初只对社会名流开放，现已发展成一所学科全面、集教育与科研于一身的世界研究型大学。

Postdoc Position in Circadian Biology and Bioinformatics

Copenhagen University

Description

We are seeking a highly motivated and dynamic researcher with expertise in analysis and interpretation of high-throughput sequencing (transcriptomics, epigenomics etc.) and mass spectrometry (proteomics, metabolomics etc.) to work in the Zierath Group in collaboration with Barrès Group and Deshmukh Group. The position is a 3-year position to start March 1, 2023, or after agreement.

Background

The Novo Nordisk Foundation Center for Basic Metabolic Research's vision is to strengthen interdisciplinary research that transforms our basic understanding of the mechanisms that underlie metabolic health and disease, and to accelerate this knowledge toward new prevention and treatment strategies. We were established in 2010 and in 2017, we moved into new laboratories, offices, and meeting rooms in the Maersk Tower www. maersktower.ku.dk.

The Center has around 260 employees who work in an international, highly collaborative research environment across a range of biomedical disciplines. You can read more about us here: www. cbmr.ku.dk.

Our research

The Zierath Group investigates the interactions between intrinsic biorhythms and external perturbations such as exercise, nutrient availability, and temperature to identify potent translational strategies for the prevention and treatment of metabolic diseases. Read more about Circadian Biology in the Zierath Group here.

The collaborators in this project are members of the Barrès Group and Deshmukh Group. TheBarrès Group focuses on how diet and physical activity, by influencing somatic and gametic cells, affect long-term metabolic health in the present and future generations. The Deshmukh Group investigates how exercise and diet influence the dynamics of proteome including secretome, post-translational modifications, subcellular organization of proteins, and the mitochondrial supercomplexome.

Project description

Type 2 diabetes is a chronic metabolic disease characterized by altered whole- body and tissue-specific metabolism, hyperglycemia, hyperinsulinemia and insulin resistance of peripheral tissues. One risk factor for the development of type 2 diabetes is the disruption of circadian rhythms. Circadian rhythms are driven by biological clocks that are synchronized by environmental stimuli such as light, diet and exercise. The research performed within this postdoctoral position will elucidate mechanisms by which physiological and epigenetic processes are modulated by the circadian clock machinery in a diurnal manner, and how synchronizing the timing of therapeutic interventions (e.g. diet and exercise) to the molecular circadian clock can optimize the treatment of type 2 diabetes. We are seeking a highly motivated researcher who will analyze and integrate a range of omics data (transcriptomics, epigenomics, metabolomics, proteomics) with comprehensive metabolic phenotyping from a range of clinical and preclinical models (e.g. cell, rodent, and human) to identify important targets in the regulation of circadian rhythms and metabolic health.

Your job

Your responsibilities will include carrying out all major computational analyses of the project: Analysing and interpreting high-throughput sequencing (RNA-seq, bisulfite sequencing, ChIP-seq) and mass spectrometry (metabolomics, proteomics) data obtained from metabolic tissues as well as previously published datasets. You will be working with a team of biologists/clinicians and bioinformaticians; therefore, you are expected to help the team with the experimental design and statistical interpretations of the experimental results.

In addition, you must have excellent communication and organizational skills as you will contribute to collaborative work with colleagues in the Zierath, Barrès and Deshmukh Groups at CBMR.

Profile We are looking for a highly motivated and enthusiastic scientist with the following competencies and qualifications:

PhD in bioinformatics, computational biology or a related field

High level of proficiency in programming and experience in applying statistical methods to genomic data (preferably in R and/or Python)

Solid experience in Linux/UNIX environment, shell scripting and high- performance computing (HPC)

Expertise in next generation sequencing (NGS) data analysis such as RNA- seq, Bisulfite-seq (WGBS, RRBS), ChIP-seq)

Experience with mass spectrometry (proteomics, metabolomics) data analysis

Experience with circadian data analysis (rhythmicity and differential rhythmicity) is desired, but not essential

Knowledge of human physiology and metabolic disorders

Demonstrated capacity for effective teamwork

Proven track record showing scientific productivity in peer-reviewed journals

Experience in supervising other researchers at different levels

Excellent English communication skills, both written and oral

Place of employment

The place of employment is at Novo Nordisk Foundation Center for Basic Metabolic Research, Maersk Tower, Panum Institute, University of Copenhagen. We offer creative and stimulating working conditions in a dynamic and international research environment.

Terms of employment

The employment as postdoc is a full-time and fixed-term position for 3 years. Starting date is March 1, 2023, or after agreement.

Salary, pension and terms of employment will be in accordance with the agreement between the Ministry of Finance and AC (Danish Confederation of Professional Associations). Depending on qualifications, a supplement may be negotiated.

Non-Danish and Danish applicants may be eligible for tax reductions, if they hold a PhD degree and have not lived in Denmark for the last 10 years.

The position is covered by the Job Structure for Academic Staff at Universities 2020.

Questions For further information please contact Associate Professor Atul Deshmukh at atul.deshmukh@sund.ku.dk; for questions regarding the recruitment procedure, please contact SUND HR CBMR at SUND-HR-CBMR@sund.ku.dk.

International applicants may find these links useful www. ism.ku.dk (International Staff Mobility) and https: // www. workindenmark.dk/ .

Application procedure Your online application must be submitted in English by clicking ‘Apply now' below. Furthermore, your application must include the following documents/attachments – all in PDF format:

1. Motivated letter of application (max. one page)

2. CV incl. education, work/research experience, language skills and other skills relevant for the position

3. A certified/signed copy of a) PhD certificate and b) Master of Science certificate. If the PhD is not completed, a written statement from the supervisor will do.

4. List of publications

Application deadline: 11 December, 2022, 23.59pm CET

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