英国弗朗西斯.克里克研究所2022年招聘博士后职位（生物医学方向）

弗朗西斯·克里克研究所（Francis Crick Institute）：2010年诺贝尔奖得主、遗传学家保罗·纳斯提议将英国伦敦两家最大的生物医学研究中心（英国国家医学研究所，英国癌症研究中心）合并在一起，建立一个巨型实验室。

2015年11月实验室将竣工，2021年，这家耗费6.5亿英镑（约63亿人民币）、占地9.3万平方米的研究所将全功率运行，将有1600位科学家和工作人员在这里工作，它将成为欧洲最大的单一生物医学实验室。

Postdoctoral Training Fellow – NW Goehring lab

Francis Crick Institute

Postdoctoral Training Fellow – NW Goehring lab

Reporting to: Nathan Goehring, Senior Group Leader

Contact term: This is a full-time, fixed term (4 years) position on Crick terms and conditions of employment.

Please note this is a rolling advert with no specific closing date. Applications will be considered as they arrive and will close once the position is filled.

Anticipated starting date of Summer 2023, though flexibility is possible.

The Research Group

Work in the Goehring lab aims to understand how cell polarity is established by polarity networks that transduce symmetry-breaking cues into stable molecular asymmetries. Our work focuses on a conserved polarity network defined by the PAR (PAR-titioning defective) proteins, which underlie polarity in diverse contexts, including defining epithelial architecture and function, driving asymmetric division of stem cells, and specifying cell fate of embryonic blastomeres.

Using the C. elegans embryo as a model, our interdisciplinary team combines genetics, quantitative imaging, in vivo biophysics, and mathematical modelling to link system-level properties of the PAR network to molecular behaviours, thereby providing a multi-scale model for how PAR proteins polarize cells in response to developmental cues and ultimately how polarized patterns are read out by the downstream pathways that define a cell’s functional polarity. For more detail, please see our website.

Position Summary

We aim to recruit a talented and motivated Postdoctoral Training Fellow to join our group. Postdoctoral Training Fellows are expected to lead their own projects, to generate and pursue independent research ideas, and to contribute to other projects on a collaborative basis (both in the lab and with external collaborators). A variety of potential projects are available. The specific project will be developed together with the successful candidate with consideration of their specific interests and experience.

Some examples of current projects include:

Modeling and manipulating PAR network feedback circuits

Quantitative exploration of kinase-substrate interactions in polarity networks

Coupling of mechanical and biochemical networks during cell polarization

Cell cycle control of cell polarity and fate specification pathways

Canalization of developmental variability during embryogenesis

Mechanisms for encoding cellular memory

Note this is a core-funded position, though successful candidates will be encouraged to pursue external fellowship support.

We welcome applications from diverse backgrounds who can bring new ideas, tools, and/or perspectives to the group.

Informal inquiries to nate.goehring@crick.ac.uk. Please include a clear statement of why you are interested and how you see yourself contributing to our group.

Key experience and competencies

The post holder should embody and demonstrate our core Crick values: bold, open and collegial, in addition to the following:

Essential

PhD (awarded or expected) in Cell and Developmental Biology, Biochemistry, Biophysics or similar. Applicants from Physics, Computer Science or Engineering backgrounds seeking to expand their skills in the context of a combined wet/dry project are also welcome to apply.

A demonstrated ability to generate and pursue independent research ideas

A demonstrated ability to work as part of an interdisciplinary team

Willingness to mentor junior members of the laboratory

Strong communication and presentation skills

Strong organisational and record-keeping skills

Track record of scientific scholarship, evidenced by preprints, publications or submitted manuscripts in refereed journals

About Us

At the Crick, we conduct research at the forefront of biomedical research. We combine rigour with an open and collaborative culture, and are outward-looking, reflecting our status as a partnership of six organisations aiming to pool knowledge, ideas and resources.

We have a wide research portfolio with no divisions or departments, bringing biomedical researchers together with clinicians, physical scientists and applied scientists from our pharmaceutical partners.

We aim to attract the most talented researchers and support them to tackle innovative research questions. Our science technology platforms provide our researchers with access to state-of-the-art technology and expertise.

We provide an excellent learning environment with dedicated education programmes in public engagement with science, education and personal development, and a postdoc training programme that prepares scientists for leadership roles in science.

If you are interested in applying for this role, please apply via Workday.

All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.

If you require a visa to work in the UK we will help support your application should you be successful

Find out what benefits the Crick has to offer:

For more information on our great pay and benefits package please click here: https://www.crick.ac.uk/careers-and-study/life-at-the-crick/pay-and-benefits

Equality, Diversity & Inclusion:

We welcome applications from all backgrounds. We are committed to providing equal employment opportunities, regardless of ethnicity, nationality, gender, sexual orientation, gender identity, religion, pregnancy, age, disability, or civil partnership, marital or family status. We particularly welcome applications from people who are Minority Ethnic as they are currently underrepresented in the Crick at this level.

Diversity is essential to excellence in scientific endeavour. It increases breadth and perspective, leading to more innovation and creativity. We want the Crick to be a place where everyone feels valued and where diversity is celebrated and seen as part of the foundation for our Institute’s success.

The Crick is committed to creating equality of opportunity and promoting diversity and inclusivity. We all share in the responsibility to actively promote dignity, respect, inclusivity and equal treatment and it is our aim to ensure that these principles are reflected and implemented in all strategies, policies and practices.

Read more on our website: https://www.crick.ac.uk/careers-and-study/life-at-the-crick/equality-diversity-and-inclusion

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