美国H. Lee Moffitt癌症中心2023年招聘博士后职位（胰腺癌转移的选择性剪接）

Postdoctoral Research Fellow: Alternative Splicing in Pancreatic Cancer Metastasis

H. Lee Moffitt Cancer Center

Job Description

About the Lab:

The Mann lab investigates the genetic and epigenetic regulation of novel tumor suppressors involved in the initiation and progression of pancreatic cancer (PDAC) that we discovered using an in vivo forward genetic screen. We are focused on the regulation of alternative splicing regulated by RBFOX2 during PDAC progression and how to leverage this splicing regulation to predict and prevent recurrent disease and/or metastatic progression. We are looking for an individual excited by inter-disciplinary approaches to investigate PDAC splicing signatures using ex vivo models, mouse models and patient samples with the goal of identifying additional splicing regulators and/or splicing events that may be explored for diagnostic or therapeutic efficacy to better treat cancer patients. More information about the lab can be viewed on our website http://labpages2.moffitt.org/mann_k.

Position Highlight:

A successful applicant will use molecular biology, genomics and proteomics to dissect the regulation of alternative splicing in PDAC and to study the functions of alternative spliced isoforms of key molecules that modulate cellular processes and signaling pathways driving pancreatic cancer development and metastasis. This individual will work both independently and collaboratively and will be part of a team that consists of basic researchers, clinicians and computational biologists.

The Ideal Candidate:

· Has a strong foundation in molecular biology and cancer biology

· Is experienced in mammalian cell culture, including ex vivo assays to assess phenotypic changes

· A background in alternative splicing and/or pancreatic cancer is highly desired

· Mouse genetics experience and familiarity with NGS is desired but not essential

Responsibilities:

· Learn research techniques that directly relate to the program’s scientific projects and goals with appropriate direction and supervision.

· Plan, conduct and document experiments independently; evaluate and interpret data with guidance.

· Develop scientific writing and presentation skills, including grant proposals, manuscript preparation and formal seminars presented to the Moffitt scientific community and at national scientific meetings.

Credentials and Qualifications:

PhD in Genetics, Molecular Biology, Biochemistry or related discipline earned within the last two years.

A competitive salary and benefits package will be offered to the successful candidate. Interested applicants should send a single PDF file that includes a current CV with recent publications, a personal statement of scientific interests and goals (2-page maximum) and contact information for three references to Dr. Karen Mann at Karen.Mann@moffitt.org.

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