美国希望之城2023年招聘博士后职位（疱疹病毒疫苗开发）

希望之城国家医疗中心(City of Hope NationalMedical Center)是一所顶尖的美国非盈利研究和治疗中心，专注于癌症、糖尿病和其他危及生命的疾病。

该医疗中心是美国国立癌症研究院（National Cancer Institution）指定的53所癌症综合中心之一，也是美国国立综合癌症网络的创立会员和中央数据协调中心。被权威新闻杂志周刊《美国新闻与世界报道》(U.S News & World Report)列为全美最佳癌症医院第七名和“美国最佳癌症和泌尿科医院”之一。

Postdoctoral Fellow - Herpesvirus Vaccine Development

City of Hope

Job Description

About City of Hope

City of Hope is an independent biomedical research and treatment organization for cancer, diabetes and other life-threatening diseases.

Founded in 1913, City of Hope is a leader in bone marrow transplantation and immunotherapy such as CAR T cell therapy. City of Hope’s translational research and personalized treatment protocols advance care throughout the world. Human synthetic insulin, monoclonal antibodies and numerous breakthrough cancer drugs are based on technology developed at the institution. AccessHope™, a subsidiary launched in 2019 serves employers and their health care partners by providing access to City of Hope’s specialized cancer expertise.

A National Cancer Institute-designated comprehensive cancer center and a founding member of the National Comprehensive Cancer Network, City of Hope is ranked among the nation’s “Best Hospitals” in cancer by U.S. News & World Report and received Magnet Recognition from the American Nurses Credentialing Center. Its main campus is located near Los Angeles, with additional locations throughout Southern California and in Arizona.

City of Hope’s commitment to Diversity, Equity and Inclusion

We believe diversity, equity and inclusion is key in serving our mission to provide compassionate patient care, drive innovative discovery, and advance vital education focused on eliminating cancer and diabetes in all of our communities. Our commitment to Diversity, Equity and Inclusion ensures we bring the full range of skills, perspectives, cultural backgrounds and experiences to our work -- and that our teams align with the people we serve in order to build trust and understanding. We are dedicated to fostering a community that embraces diversity - in ideas, backgrounds and perspectives; this is reflected in our work and represented in our people.

Position Summary

The Beckman Research Institute of City of Hope is looking for a talented Postdoctoral Fellow.

Our laboratory invites highly motivated candidates to apply for an interdisciplinary postdoctoral scholar position. Our laboratory focuses on oncogenic herpesviruses, in particular Epstein-Barr virus (EBV), Kaposi-sarcoma associated herpesvirus (KSHV), and the rhesus macaque EBV homologue rhesus lymphocryptovirus (rhLCV), and on developing prophylactic and therapeutic strategies against primary infection with these viruses and their associated cancers. The postdoctoral scholar will be working on projects with the overarching goal of designing and testing gamma herpesvirus vaccine candidates and immuno-therapeutics in various preclinical animal models.

The scholar will be leading projects that are in collaborations between the City of Hope Cancer Center and other institutions within and outside the USA. Importantly, City of Hope has good laboratory practice (GLP) and Current Good Manufacturing Practice (cGMP) FDA-approved biologic facilities (https://www.cityofhope.org/research/biological-and-cellular-gmp-manufacturing-facility/cbg---center-for-biomedicine-and-genetics) to produce the candidate vaccines and immunotherapeutics in house and test them in preclinical animal models and in Phase I clinical trials.

Basic education, experience and skills required for consideration:

· Candidates should have a Ph.D., Ph.D./M.D, M.D., or Ph.D./DVM, with a record of peer-reviewed publications.

· Molecular biology, protein expression, purification, crystallization, and functionalization.

· Generation and characterization of monoclonal antibodies for diagnostic and therapeutic purposes.

· In vitro methods for assessing immunological responses, particularly antibody assays (such as ELISA, isolation/depletion of antigen-specific antibodies, viral neutralization assays, etc.), T cell response and toxicity assays.

· In vivo immunization and/or tumor investigations, specifically murine (transgenic and humanized), rabbit and NHP models.

· Ability to design and execute laboratory experiments, critically interpret experimental results, and present data in a clear and concise manner

· Ability to participate in the preparation of grant applications, scientific publications and investigational new drug applications.

· Good organization, excellent writing and oral communication, and ability to work in an interdisciplinary team are essential.

Additional information:

· As a condition of employment, City of Hope requires staff to comply with all state and federal vaccination mandates.

· For more information about Ogembo’s lab, please visit here.

Salary / Pay Rate Information:

Pay Rate: $31.00 - $34.23 / hour

The estimated pay scale represents the typical [salary/hourly] range City of Hope reasonably expects to pay for this position, with offers determined based on several factors which may include, but not be limited to, the candidate’s experience, expertise, skills, education, job scope, training, internal equity, geography/market, etc. This pay scale is subject to change from time to time.

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