当前位置: 硕博英才网 > 博士后招聘 > 国外博士后招聘 >

美国罗斯威尔帕克综合癌症中心2023年招聘博士后(肿瘤微环境、表观遗传学、代谢与转录)

发布时间:2023-04-04 10:11信息来源:美国罗斯威尔帕克综合癌症中心

美国罗斯威尔帕克综合癌症中心2023年招聘博士后(肿瘤微环境、表观遗传学、代谢与转录)

Postdoctoral fellow in Tumor Microenvironment, Epigenetics, Metabolism and Transcription

Roswell Park Comprehensive Cancer Center

Location: Buffalo, NY

Job Number: 7135128

Posting Date: Mar 20, 2023

Salary / Pay Rate: Upto $57,000 + benefits +health insurance

Application Deadline: Open Until Filled

Job Description

Postdoctoral position is open for highly motivated candidates in the laboratory of Dr. Subhamoy Dasgupta, Department of Cell Stress Biology, Roswell Park Comprehensive Cancer Center, NY- a National Cancer Institute (NCI) designated comprehensive cancer center. Some of the ongoing research directions in Dasgupta lab are:

(a) Discovering tumor metabolic adaptations that promote metastatic progression.

(b) Understanding the mechanisms regulating organ specific adaptation of tumors leading to metastatic colonization. Strong focus on bone-metastatic tumors.

(c) Deciphering epigenetic landscape of aggressive tumors and identifying how nutrient signaling and metabolism modulates histone acetylation/methylation impacting chromatin accessibility.

(d) Nuclear receptor and coactivator dependent transcriptional regulation of hormone-dependent tumors and defining the mechanisms driving therapeutic resistance.

(e) Interrogate the tumor-immune microenvironment and discover the mechanisms driving tumor-immune escape.

State of art facilities such as proteomics, genomics (scRNAseq, RNAseq, ATACseq, ChIPseq, etc.), and metabolomics (steady state, isotope tracing, tumor interstitial fluid, etc.) along with molecular biology and immunological techniques are widely used in the laboratory. Multiple models systems, including Genetically Engineered Mouse Models (GEMMs), patient-derived xenograft (PDX), and syngeneic tumor models are used to address challenging mechanisms in cancer progression and metastasis. Currently the laboratory is funded by multiple grants from National Cancer Institute (NCI), NIH Director’s Award, Department of Defense (DoD), and other private foundations. Recent publications from the lab:

a) Dasgupta S, et al, Journal of Clinical Investigation, 2015, PMID: 25664849;

b) Dasgupta S, et al, Nature, 556, 249–254, 2018, PMID: 29615789;

c) Sawant Dessai A, et al, Cancer Research, 2020, PMID: 33115805;

d) Dai T., et al, Cell Reports, 2022, PMID: 36476868;

e) Wu YH, et al, Molecular Cancer Therapeutics, 2022, PMID: 35666809.

The search is primarily targeted towards scientists who are completing their PhD or have recently graduated with first author publications demonstrating their skills in any related areas of gene transcription, epigenetics, biochemistry, cancer biology, and immunology. Experience of working with mouse models will be preferred. The candidate should possess outstanding written and verbal communication skills. Candidates from all backgrounds are encouraged to apply. We welcome diversity!

Roswell Park Comprehensive Cancer Center, one of the world’s oldest cancer centers established in 1898, is known for numerous seminal basic science and translational discoveries in oncology. Roswell Park has state-of-the-art research infrastructure enabling all aspects of modern biomedical research – from discovery work towards clinical validation – and provides a highly stimulating academic and clinical environment.

Location: Buffalo, New York

Salary: Competitive with healthcare benefits

Discipline: Cancer Biology, Immunology, Molecular Biology, Signal Transduction, Cell Biology

Lab website: www.subhamoydasguptalab.com

Contact Information:

Subhamoy Dasgupta

subhamoy.dasgupta@roswellpark.org

Roswell Park Comprehensive Cancer Center

Buffalo,New York

United States

更多最新博士后招收信息请关注博士后招聘网微信公众号(ID:boshihoujob)

祝君:学业有成、学成归来

声明:凡本网注明“来源:XXX”的文/图等稿件,本网转载出于传递更多信息及方便产业探讨之目的,并不意味着本站赞同其观点或证实其内容的真实性,文章内容仅供参考。如其他媒体、网站或个人从本网站转载使用,须保留本网站注明的“来源”,并自负版权等法律责任。作者如果不希望被转载或者联系转载等事宜,请与我们联系。邮箱:shuobojob@126.com。

微信公众号

关注硕博英才网官方微信公众号

硕博社群

更多社群>