招聘简介：

博士后助理（遗传性耳聋研究）

·迈阿密大学

·地点：佛罗里达州迈阿密

·工作编号：7057129（参考号：R100029004）

·发布日期：2019年4月26日

·申请截止日期：开放至填写

职位描述

刘学忠博士和他在迈阿密大学米勒医学院的合作研究小组指导下的博士后职位，可用于基因/细胞/药物治疗遗传性耳聋，包括神经纤维瘤病II型（NF2）。

我们正在寻找在遗传学、功能基因组学、分子生物学、干细胞生物学或相关学科领域拥有博士、医学博士或同等学位的具有实验室经验的杰出科学家加入我们的实验室，作为识别与耳聋相关的遗传因素的项目的一部分，并为听力损失的治疗。这些职位提供了一个独特而令人兴奋的机会，作为一个多学科和协作团队的一部分，致力于开发尖端技术，研究耳聋和内耳发育，并直接应用于治疗人类听力损失。我们已经在人类中发现了多个新的耳聋基因，并正在开发动物模型和诱导多能干细胞（ipsc）系，以研究这些基因在听力丧失发展中的作用。我们特别感兴趣的是，在以下领域中，提出了新的生物学方法，如基于crispr的基因疗法来治疗遗传疾病中的听力损失：1）发展基因组编辑或基于aav的基因疗法来挽救人类听力损失的小鼠模型中的听力；2）推进使用crispr纠正疾病p的研究。使用人类耳聋患者的ips细胞进行的过敏反应；3）筛选和测试已获FDA批准的药物对小鼠和人类耳聋基因缺陷细胞系和人类耳聋动物模型的有效性的临床前研究；4）开发新的传递途径，用于在其他内耳细胞类型中应用crispr（支持细胞、血管纹和神经节神经元）用于治疗不同细胞起源的听力损失。应聘者应具有独立性和高度的积极性，具有较强的沟通能力和批判性思维能力，并致力于团队合作和协作。候选人将利用动物模型、ipsc技术和crispr基因组编辑，因此，在这些技术方面的经验是可取的，尽管不是必需的。其他职责包括参与项目规划、赠款和手稿撰写，以及指导更多的实验室初级成员。本项目的主要研究人员是刘学忠博士、博士生苏珊·布兰顿博士、凯瑟琳·沃尔兹博士和德里克·戴克肖恩博士。一个成功的候选人（博士，硕士/博士或医学博士）应该在分子生物学，动物或细胞为基础的疾病模型，遗传学和基因组学，和/或神经科学有很强的背景。有听力损失或内耳研究的经验是有益的，但不是必需的。

英文原文：

Postdoctoral Associate (Genetic Deafness Research)

· University of Miami

· Location: Miami, FL

· Job Number: 7057129 (Ref #: R100029004)

· Posting Date: Apr 26, 2019

· Application Deadline: Open Until Filled

Job Description

A postdoctoral position supervised by Dr. Xuezhong Liu and his Co-investigator team at the University of Miami Miller School of Medicine, is available to work on the application of gene-/cell-/drug-based approaches to treat genetic deafness including Neurofibromatosis type II (NF2).

We are looking for outstanding scientists with laboratory experience holding a PhD, MD or equivalent degree in the fields of genetics, functional genomics, molecular biology, stem cell biology or related disciplines to join our laboratory as part of a project to identify genetic factors linked to deafness and develop therapeutic strategies for the treatment of hearing loss. These positions offers an unique and exciting opportunity to work as part of a multidisciplinary and collaborative team engaged in developing cutting-edge technologies to study deafness and inner ear development with direct application for treating hearing loss in humans. We have identified multiple new deafness genes in humans and are developing animal models and induced pluripotent stem cell (iPSC) lines to study the role that these genes play in the development of hearing loss. We are particularly interested in advancing novel biological approaches such as CRISPR-based gene therapy to treat hearing loss in genetic diseases in the following areas: 1) Development of genome editing or AAV based gene therapy to rescue hearing in the mouse models of human hearing loss; 2) Advance the study of using CRISPR to correct disease phenotype using iPS cells from human deafness patients; 3) preclinical studies in screening and testing the effectiveness of already FDA-approved drugs on mouse and human deafness gene-deficient cell lines and in animal models of human deafness; 4) Development of new delivery route for application of CRISPR in other inner ear cell types (supporting cells, stria vascularis and ganglion neurons) to treat hearing loss with different cellular origins. Candidates should be independent and highly motivated with strong communication and critical thinking skills, as well as a dedication to teamwork and collaboration. Candidates will utilize animal models, iPSC technology, and CRISPR genome editing, as such, experience in these technologies is desirable although not required. Other duties will include participating in project planning, grant and manuscript writing, and the mentoring of more junior members of the laboratory. Lead investigators for this project are Drs. Xuezhong Liu MD, PhD, Susan Blanton, PhD, Katherina Walz, PhD, and Derek Dykxhoorn, PhD. A successful candidate (Ph.D, M.D/Ph.D or MD) should have a strong background in molecular biology, animal or cell-based models of disease, genetics and genomics, and/or neuroscience. Experience in hearing loss or inner ear research would be beneficial but is not required.

Minimum Qualifications

Ph.D., M.D., or other doctoral-level degree in a related field of study. Possess a strong background in molecular biology, animal, or cell-based models of disease, genetics, and genomics, and/or neuroscience. Must be independent and highly motivated with strong communication and critical thinking skills, as well as a dedication to teamwork and collaboration.

UHealth-University of Miami Health System, South Florida's only university-based health system, provides leading-edge patient care powered by the ground breaking research and medical education at the Miller School of Medicine. As an academic medical center, we are proud to serve South Florida, Latin America and the Caribbean. Our physicians represent more than 100 specialties and sub-specialties, and have more than one million patient encounters each year. Our tradition of excellence has earned worldwide recognition for outstanding teaching, research and patient care. We're the challenge you've been looking for.

Patient safety is a top priority. As a result, during the Influenza ("the flu") season (September through April), the University of Miami School of Medicine requires all employees who provide ongoing services to patients, work in a location (all Hospitals and clinics) where patient care is provided, or work in patient care or clinical care areas, to have an annual influenza vaccination. Failure to meet this requirement will result in rescinding or termination of employment.