招聘简介：

·德州大学安德森癌症中心

职位描述

两个博士后职位在Yonathan Lissanu Deribe实验室，医学博士，博士，德克萨斯大学医学博士安德森癌症中心心血管和胸外科，基因组医学部联合任命。我们的实验室致力于了解染色质生物学在癌症发展中的作用，识别癌症的遗传易损性和新型癌症治疗学的发展（Lissanu Deribe等人，自然医学2018年，Lissanu Deribe等人，PNAS 2016年）。

为此，我们利用基因工程小鼠（GEM）癌症模型，各种功能基因组方法，包括全基因组CRISPR敲除筛选和表观基因组技术，如高通量RNA-和芯片序列和ATAC序列。

我们计划扩大在基因定义肿瘤中识别新的治疗靶点的努力。最近，我们发现了新的蛋白质水解靶向嵌合分子（protacs），诱导选择性降解癌蛋白，并赢得了一些资助，进一步发展这些分子作为治疗。

这两个职位都将提供癌症遗传学、染色质生物学、功能基因组学和癌症治疗发展方面的深入接触和培训。

英文原文：

· The University of Texas M. D. Anderson Cancer Center

Job Description

Two postdoctoral positions are available in the laboratory of Yonathan Lissanu Deribe, M.D, Ph.D., in the Department of Cardiovascular and Thoracic Surgery at The University of Texas MD Anderson Cancer Center with joint appointment in the Department of Genomic Medicine. Our lab focuses on understanding the role of chromatin biology in cancer development, identifying genetic vulnerabilities of cancers and development of novel cancer therapeutics (Lissanu Deribe et al Nature Medicine 2018, Lissanu Deribe et al PNAS 2016).

To this end, we utilize genetically engineered mouse (GEM) models of cancer, various functional genomic approaches including genome-wide CRISPR knockout screens and epigenomic technologies such as high-throughput RNA- and ChIP-Seq and ATAC-Seq.

We plan to expand our efforts in identifying novel therapeutic targets in genetically defined tumors. Recently, we have discovered novel proteolysis targeting chimeric molecules (PROTACs) that induce selective degradation of oncoproteins and won several grants to further develop these molecules as therapies.

Both positions will provide deep exposure and training in cancer genetics, chromatin biology, functional genomics and cancer therapeutic development.

We seek highly motivated individuals with a Ph.D. or equivalent degree in all areas of molecular & cell biology, biochemistry or genetics. Candidates with training in statistics or programming expertise, in particular R/Python and interest in the application of state-of-the-art computational/statistical methods to complex data are particularly encouraged to apply. Experience with hands on mice work is a big plus but not required.

The Lissanu laboratory is situated in a highly dynamic and stimulatory environment for learning. MD Anderson Cancer Center is rated number one hospital in cancer care in the United States. The institute offers active graduate and postdoctoral training programs and the unmatched scientific environment of the Texas Medical Center, the world's largest biomedical center. Competitive salary and benefits are provided to post-doctoral fellows. Houston is the fourth largest city in the USA with a vibrant and booming economy. Houston has a mild winters and is sunny year round.

Responsibilities:

• Use cutting-edge approaches to seek novel therapeutic targets for human cancers

• Be responsible for the design and execution of experimental work, data analysis and write up

• Attend and present at internal and international meetings

• Be expected to publish data in top scientific journals

Job requirements:

• PhD or equivalent in Molecular Biology, Biochemistry, Genetics or related field

• Good publication record

• Excellent communication skills is required.

Please send a cover letter, curriculum vitae, names and contact information of three references, and a brief summary of past research accomplishments and future research plans to: Yonathan Lissanu Deribe, M.D, Ph.D. (ylissanu@mdanderson.org )