招聘简介：

旧金山加利福尼亚大学

医学部肺与危重病治疗科

一位积极性很高的科学家可以利用基因工程小鼠、细胞系和人类样本的组合来研究气道平滑肌中与疾病相关的力传递的基本生物学。该小组正致力于开发新的治疗方法，通过结合体外收缩试验、体内气道高反应性评估和双光子显微镜，来针对哮喘患者气道平滑肌过度收缩进行治疗。我们小组的一个主要焦点是利用已建立的多学科合作将我们的发现转化为治疗学，以开发和筛选有效的靶蛋白小分子抑制剂。感兴趣的候选人可以查看我们小组最近的代表性出版物：Sundaram等人JCI2017。

英文原文：

University of California, San Francisco

Division of Pulmonary & Critical Care, Department of Medicine

A postdoctoral position is available for a highly motivated scientist to focus on the basic biology of force transmission in airway smooth muscle with disease relevance using a combination of genetically engineered mice, cell lines, and human samples. The group is working to develop novel therapeutic approaches to target excessive airway smooth muscle contraction in asthma using a combination of ex vivo contraction assays, in vivo assessments of airway hyperresponsiveness, and two-photon microscopy. A major focus of our group is to translate our findings into therapeutics using established multidisciplinary collaborations to develop and screen potent small molecule inhibitors of target proteins. Interested candidates can review a representative recent publication from our group: Sundaram et al. JCI2017.

Career development opportunities include development of scientific presentation, writing skills, and presentation at national and international meetings. Requirements include:

o Ph.D., M.D. or M.D./Ph.D. degree and fluency in English

o Highly proficient in a variety of basic molecular biology and cell biology techniques evident by peer-reviewed publications

o Demonstrated ability to work as part of a team and independently develop, guide, and complete research projects

o Strong ability to troubleshoot experiments and solve problems

o Experience with mouse husbandry, cell culture, imaging, and flow cytometry preferred

Candidates should be self-motivated, critical thinkers, collegial, and creative. Interested candidates should send a brief statement of career goals and research interests, updated CV, along with the name and contact information of three references to Dr. Aparna Sundaram at: aparna.sundaram@ucsf.edu