招聘简介：

博士后研究员、计算和统计癌症基因组学

职位描述：

国家癌症研究所病理学实验室正在寻找博士后研究员从事癌症基因组学和表观基因组学项目。我们研究的癌症类型主要集中在原发性人脑胶质瘤（关于我们发表的研究，请参见https://www.ncbi.nlm.nih.gov/pubmed/？术语=Aldape+K）。实验室的首要目标是利用计算技能从大规模多组学数据中解释生物模式，最终目标是根据生物数据诊断和分类人类癌症。

成功的申请人将参与开发新的统计和遗传方法、理论和计算工具以及机器学习策略，以分析和整合基因组和表观基因组数据与人类癌症病理评估。获取广泛的核心设施，包括生物信息学、微阵列、细胞基因组学、测序和病理图像存储的核心，为机器学习和深度学习计算方法的发展提供了令人兴奋的机会。职业发展机会广泛，旨在提供机会与一系列学科和生物医学科学领域的顶尖专家互动，并将候选人培养成全面、独立的研究人员，为未来的发展做好准备。

NIH拥有丰富的研究环境，拥有无数的合作机会和生物医学研究的前沿技术资源。病理学实验室（LP）在Eytan Ruppin（https://www.ncbi.nlm.nih.gov/pubmed/）领导的组织内项目中积极与癌症数据科学实验室（CDSL）互动。术语=ruppin+e）。他在CSDLS的团队专门研究各种计算方法，分析和整合癌症多组学数据，以更好地了解癌症生物学、分类和患者的新治疗选择。利用LP和CDSL独有的资源，将为计算生物学家提供最先进的职业发展机会。癌症分子分类专家（LP主管Kenneth Aldape博士）和癌症多组学数据整合专家（CDSL主管Eytan Ruppin博士）都致力于共同指导和推进未来的独立研究者。

美国国立卫生研究院（NCI）壁内项目病理学实验室位于美国马里兰州贝塞斯达，其使命是在临床诊断、癌症研究和教育方面达到最高水平。培训项目通过NCI培训办公室和NIH校内培训和教育办公室提供。国家卫生研究院致力于在其培训和就业项目中建立一个多元化的社区。

英文原文：

Post-Doctoral Fellowship, Computational and Statistical Cancer Genomics

Position Description:

Laboratory of Pathology of National Cancer Institute is looking for postdoctoral researcher to work on cancer genomics and epigenomics project. We study variety of cancer types with focus on primary human brain gliomas (for our published work, please see https://www.ncbi.nlm.nih.gov/pubmed/?term=aldape+k). The overarching goal of the lab is to use computational skills to interpret biological patterns from large scale multi-omic data with ultimate goal to diagnose and subclassify human cancer accordingly to biological data.

The successful applicant will be involved in development of new statistical and genetic methods, theory and computational tools and machine learning strategies for analysis and integration of genomic and epigenomic data with pathologic evaluation of human cancer. Access to extensive core facilities including cores in bioinformatics, microarrays, cytogenomics, sequencing and pathological image depositories provides exciting opportunities for development of machine learning and deep learning computational approaches. Career development opportunities are extensive and aimed to provide the opportunity to interact with leading experts in a range of disciplines and biomedical science, and to develop candidates into well rounded, independent investigators ready for future advancement.

The NIH has a rich research environment with countless opportunities for collaboration and cutting-edge technology resources for biomedical research. Laboratory of Pathology (LP) actively interacts with the Cancer Data Science Laboratory (CDSL) in the intramural program, led by Eytan Ruppin (https://www.ncbi.nlm.nih.gov/pubmed/?term=ruppin+e). His group in the CSDLspecializes in a variety of computational approaches, analyzing and integrating cancer multi-omics data to better understand cancer biology, classification, and new therapeutic options for patients. Access to the resources unique to the LP as well as to the CDSL, will provide state-of-the-art career development opportunities for computational biologists. Both experts in cancer molecular classification (Dr. Kenneth Aldape, Chief of LP) and cancer multi-omics data integration (Dr. Eytan Ruppin, Chief of the CDSL) are committed to co-mentor and advance independent investigators of the future.

The Laboratory of Pathology within the intramural program of the NCI, NIH, is located in Bethesda, Maryland, USA. Its mission is to achieve the highest level of quality in clinical diagnostics, cancer research and education. Training programs are made available through the NCI Training Office and the NIH Office of Intramural Training and Education. The NIH is dedicated to building a diverse community in its training and employment programs.

Qualifications:

The successful candidate will have a strong quantitative research background with a PhD in areas such as Statistical Genetics, Statistical Methods, Machine Learning, Deep Learning or Computer Science; practical experience working with large real-world genetic data sets, developing new methods, statistical computing, and producing high-quality published work. We expect the candidate to be motivated, creative, communicative and happy to work in a collaborative and inter-disciplinary environment.

To Apply:

Suitably qualified candidates should submit their curriculum vitae, cover letter, and the names and contact information (email and phone #) for three referees to:

Dr. Zied Abdullaev

Laboratory of Pathology

Center for Cancer Research

National Cancer Institute

Bethesda, MD 20892

United States

zied.abdullaev@nih.gov

Salary will be commensurate with research experience in the NIH system.

Disclaimers: This position is at the National Cancer Institute, and is therefore subject to a background investigation. The NIH is dedicated to building a diverse community in its training and employment programs.

AboutNIH

The National Institutes of Health is made up of 27 different components called Institutes and Centers. Each has its own specific research agenda, often focusing on particular diseases or body systems. All but three of these components receive their funding directly from Congress and administrate their own budgets. NIH leadership plays an active role in shaping the agency’s research planning, activities, and outlook. The Office of the Director is the central office, responsible for setting policy for NIH and for planning, managing, and coordinating the programs and activities of all the NIH components.