招聘简介：

该职位可立即获得高动力博士学位，重点是使用造血干细胞（hscs）和基因疗法治疗多系统退行性疾病的遗传途径，尤其是神经肌肉疾病。本项目采用的基因治疗技术包括慢病毒载体和CRISPR/CAS9介导的基因编辑。候选人还将使用人类和小鼠的HSC体外检测和小鼠遗传疾病模型。该项目还包括对HSC衍生细胞拯救退化神经肌肉组织的机制的研究。成功的候选人将成为一个具有尖端仪器和设施的刺激性和协作性科学环境的一部分。

英文原文：

Available immediately for highly motivated Ph.Ds, the position focuses on the use of hematopoietic stem cells (HSCs) and gene therapy for the treatment of inherited approaches for multi-systemic degenerative disorders, and in particular neuromuscular diseases. Gene therapy technologies employed in the project include lentivirus vectors and CRISPR/Cas9-mediated gene editing. The candidate will also use human and mouse HSCs in in vitro assays and murine models of genetic disorders. The project also includes the investigation of the mechanism involved in the rescue of degenerative neuromuscular tissues by HSC-derived cells. Successful Candidates will be part of a stimulating and collaborative scientific environment with cutting-edge instrumentation and facilities.

Qualifications Required and Preferred Academic Background

The candidate should be highly self-motivated, with strong communication and interpersonal skills and the ability to work independently, has a PhD, with a strong background in stem cell biology, gene therapy and CRISPR/Cas9-mediated gene editing and neuroscience. Experience with mice is required.

If you are interested, please submit your C.V. to Stephanie Cherqui scherqui@ucsd.edu.