招聘简介：

职称：博士后培训研究员 - 莫洛德索夫实验室

地点：伦敦米德兰路弗朗西斯克里克研究所

合同：定期（4年），全职

薪酬：具有竞争优势，受技能和经验的影响

空缺ID：10846

简短的摘要

弗朗西斯克里克研究所的机械生物学和生物物理学小组正在寻找一位高素质的生物化学家加入我们的跨学科团队。 Maxim Molodtsov领导，我们研究分子原理和力量，导致精确和大规模的DNA重排和准确的DNA分离，我们使用广泛的单分子技术，包括力谱，单分子成像和单分子FRET。我们还继续开发新工具，以了解移动和重组DNA的机器的机制。在过去，我们对驱动DNA组织和细胞骨架重排的机制进行了重要发现，并开发了新的成像物理工具。

候选人应具有蛋白质生物化学和分子生物学的扎实背景。预计它们具有强大的出版记录和对定量生物物理方法和/或单分子方法的浓厚兴趣。不需要显微镜，生物物理和/或力谱的经验，但欢迎。

英文原文：

Job title: Postdoctoral Training Fellow – Molodtsov Laboratory

Location: The Francis Crick Institute, Midland Road, London

Contract:Fixed-term (4 years), full time

Salary:Competitive with benefits, subject to skills and experience

Vacancy ID: 10846

Short summary

The mechanobiology and biophysics group at the Francis Crick Institute is looking for a highly qualified biochemist to join our interdisciplinary team. Lead by Maxim Molodtsov, we investigate molecular principles and forces that lead to precise and large-scale DNA rearrangements and accurate DNA segregation and we use broad range of single-molecule techniques including force spectroscopy, single-molecule imaging and single-molecule FRET. We also continue developing new tools to understand mechanistics of the machinery that moves and reorganizes DNA. In the past we made important discoveries of mechanisms that drive DNA organization and cytoskeleton rearrangements as well as developed new physical tools for imaging.

Candidates should have a solid background in protein biochemistry and molecular biology. They are expected to have a strong publication record and strong interest in quantitative biophysical methods and/or single-molecule methods. Experience with microscopy, biophysics and/or force spectroscopy is not required but welcome.

Project scope

Positions are available in two areas: (1) Microtubule-based cytoskeleton rearrangements and chromosome movements; (2) DNA organization and segregation during cell division.

The successful candidate will use in vitro assays to reconstitute biochemically multicomponent systems that drive these processes. To investigate the underlying mechanisms, they will use multi-wavelength TIRF microscopy and/or single-molecule imaging including single-molecule FRET and/or optical trapping as well as advanced data processing.

The project will benefit from close collaborations with leading experts in single-molecule imaging and force-spectroscopy both within the group and externally at the Crick and Physics Department of the University College London with which we are affiliated. The candidate is expected to drive their own project and participate and contribute to interdisciplinary team that works on developing new tools for investigating reorganization of cytoskeleton and DNA by motor and non-motor complexes that generate and respond to mechanical forces.

About us

The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.

An independent organisation, its founding partners are the Medical Research Council (MRC), Cancer Research UK, Wellcome, UCL (University College London), Imperial College London and King’s College London.

The Crick was formed in 2015, and in 2016 it moved into a new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under in one building in Europe.

The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; developing emerging talent and exporting it the rest of the UK; public engagement; and helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy.

o If you are interested in applying for this role, please apply via our website.

o The closing date for applications is 20 June 2019 at 23:30.

All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.