招聘简介：

高级博士后研究员

申请被邀请一位博士后研究员加入位于英国诺里奇的约翰·因尼斯中心的卡罗琳·迪恩教授的实验室。

具有丰富博士后经验的候选人将被考虑担任SC5级的高级博士后研究员职位。在其职业生涯早期阶段的候选人将被考虑担任SC6级的博士后研究员职位。

背景：

约翰·因尼斯中心是一个独立的国际植物科学、遗传学和微生物学卓越中心。

DEAN小组的总体目标是了解什么能定量地调节热环境中的sflc表达，以及如何在冷环境中转换为表观静默状态。（https://www.jic.ac.uk/people/caroline-dean/）

角色：

成功的候选人将研究拟南芥基因座FLC的表观遗传转换机制。这个位点为研究组蛋白修饰、非编码RNA和转录动力学之间的基本染色质途径提供了一个很好的系统。

该项目将涉及到在长时间暴露于寒冷之前、期间和之后解剖不同的机制，通过其反义RNA（COOLAIR）调节FLC的表达。

英文原文：

Senior – Postdoctoral Researcher

Applications are invited for a Postdoctoral Researcher to join the Laboratory of Professor Caroline Dean at the John Innes Centre based in Norwich, UK.

Candidates with substantial postdoctoral experience will be considered for the Senior Postdoctoral Researcher post, at grade SC5. Candidates at an earlier stage in their career will be considered for the Postdoctoral Researcher post, at grade SC6.

Background:

The John Innes Centre is an independent, international centre of excellence in plant science, genetics and microbiology.

The overall aim of the Dean group is to understand what quantitatively regulatesFLC expression in the warm, and how it is switched to an epigenetically silent state in the cold. (https://www.jic.ac.uk/people/caroline-dean/)

The role:

The successful candidate will study the mechanism of epigenetic switching at the Arabidopsis locus FLC. This locus provides an excellent system to study fundamental chromatin pathways linking histone modifications, non-coding RNA and transcriptional dynamics.

The project will involve dissection of the different mechanisms by which expression of FLC is regulated by its antisense RNA (COOLAIR), before, during and after exposure to prolonged cold.

The ideal candidate:

Candidates should possess a PhD in molecular biology/cell biology, with experience in chromatin analysis and confocal microscopy (SC5 and SC6). A proven record in scientific writing is essential, as is experience of oral research presentations. In order to be considered for the senior post (SC5), candidates should have demonstrated excellence and productivity in the relevant science and ideally possess skills in live imaging and super resolution microscopy.

Additional information:

Appointments made at Postdoctoral Researcher level (SC6) will attract an annual salary of £31,250 – £38,100. Appointments made at Senior Postdoctoral Researcher level (SC5) will attract an annual salary of £39,150 – £47,850. Salaries are dependent on qualifications and experience.

This is a fulltime post for a period of 3 years in the first instance.

Interviews will be held on 10th July 2019.

For further information and details of how to apply, please visit our web site http://jobs.jic.ac.uk or contact the Human Resources team on 01603 450462 or nbi.recruitment@nbi.ac.uk quoting reference 1003696.

We are an equal opportunities employer, actively supporting inclusivity and diversity. As a Disability Confident organisation, we guarantee to offer an interview to all disabled applicants who meet the essential criteria for this vacancy. The John Innes Centre is also proud to hold a Gold Award from Athena SWAN and is a member of Stonewall’s Diversity Champions programme.

The closing date for applications will be 16th June 2019.

The John Innes Centre is a registered charity (No. 223852) grant-aided by the Biotechnology and Biological Sciences Research Council and is an Equal Opportunities Employer.