招聘简介：

博士后助理（眼科-药物发现/开发）

·迈阿密大学

·地点：佛罗里达州迈阿密

·工作编号：7057369（参考号：R100030943）

·发布日期：2019年5月20日

·申请截止日期：开放至填写

职位描述

迈阿密大学米勒医学院巴斯科-帕尔默眼科研究所的眼科正在寻找两名积极的博士后助理，他们在分子/细胞生物学和动物研究方面具有丰富的研究经验，有助于发现和开发生物药物。这些职位是美国国立卫生研究院资助的在巴斯科姆帕尔默眼科研究所开发新型药物疗法的项目的一部分。《美国新闻与世界报道》（U.S.News and World Report）连续15年（2004-2018年）将巴斯科姆帕尔默眼科研究所列为1眼科医院。

研究将集中于开发下一代针对各种血管疾病的靶向抗血管生成疗法。实验室最近开发了唯一一种具有广泛适用性的配体组学技术，以发现不同疾病（包括但不限于血管生成性疾病）的新疗法的高质量药物靶点（PMID:29326083）。利用这项强大的技术，我们发现了非常有希望的药物靶点，并正在开发针对各种眼部血管疾病的靶点抗血管生成疗法（PMID:28330905）。该项目将在不同阶段对候选药物进行调查。这些包括动物模型中治疗血管生成性疾病的人源化抗体的特征描述，体外和体内新药物靶点的分析，以及发现其他未知药物靶点的配体组学筛选。研究活动包括配体组学分析、分子和细胞研究、蛋白质分析、抗体表征、受体识别和表征、治疗血管渗漏和动物模型病理性新生血管的疗法、临床前毒理学和药代动力学研究。

英文原文：

Postdoctoral Associate (Ophthalmology - Drug Discovery/Development)

· University of Miami

· Location: Miami, FL

· Job Number: 7057369 (Ref #: R100030943)

· Posting Date: May 20, 2019

· Application Deadline: Open Until Filled

Job Description

The Department of Ophthalmology at the Bascom-Palmer Eye Institute, University of Miami Miller School of Medicine is searching for two highly-motivated Postdoctoral Associates with strong research experience in molecular/cellular biology and animal research for biological drug discovery and development. These positions are part of NIH-funded projects to develop novel drug therapies at Bascom Palmer Eye Institute. Bascom Palmer Eye Institute has been ranked as the #1 eye hospital in the past 15 consecutive years (2004 -2018) by U.S. News and World Report.

Research will focus on developing next-generation targeted anti-angiogenic therapies for various vascular diseases. The laboratory recently developed the only technology of ligandomics with broad applicability to discover high-quality drug targets for novel therapies of different diseases, including but not limited to angiogenic diseases (PMID: 29326083). Using this powerful technology, we discovered highly promising drug targets and are developing targeted anti-angiogenic therapies for various ocular vascular diseases (PMID: 28330905). This project will investigate drug candidates in various stages. These include characterization of humanized antibodies to treat angiogenic diseases in animal models, analysis of novel drug targets in vitro and in vivo, and ligandomics screening to discover additional unknown drug targets. The research activities include ligandomics analysis, molecular and cellular studies, protein analyses, antibody characterizations, receptor identification and characterization, therapies to treat vascular leakage and pathological neovascularization in animal models, preclinical toxicology and pharmacokinetics studies.

Minimum Qualifications

Candidates must have a Ph.D. and/or MD, have productive scientific contributions through publication of high impact peer-reviewed papers, and show strong commitment to science. Applicants with advanced skills in molecular biology, cell biology, protein biochemistry, immunohistochemistry and animal research are highly desired. Experience in bioinformatics analysis is a plus. Excellent verbal and written communication skills are required. This position represents an excellent opportunity for career development in disease mechanism research and drug target discovery.

If interested, please complete an online application and send a CV, 1-2 page summary/Cover letter describing past accomplishments and 3 references, including contact information to Dr. Wei Li at w.li@med.miami.edu. Salary is based on NIH recommendation. Positions are available immediately.

UHealth-University of Miami Health System, South Florida's only university-based health system, provides leading-edge patient care powered by the ground breaking research and medical education at the Miller School of Medicine. As an academic medical center, we are proud to serve South Florida, Latin America and the Caribbean. Our physicians represent more than 100 specialties and sub-specialties, and have more than one million patient encounters each year. Our tradition of excellence has earned worldwide recognition for outstanding teaching, research and patient care. We're the challenge you've been looking for.

Patient safety is a top priority. As a result, during the Influenza ("the flu") season (September through April), the University of Miami School of Medicine requires all employees who provide ongoing services to patients, work in a location (all Hospitals and clinics) where patient care is provided, or work in patient care or clinical care areas, to have an annual influenza vaccination. Failure to meet this requirement will result in rescinding or termination of employment.