招聘简介：

骨髓瘤分子机制博士后研究员

·希望之城

·地点：加利福尼亚州杜阿尔特

·工作编号：7057370

·发布日期：2019年5月20日

职位描述

希望之城贝克曼研究所正在寻找一位有才华的博士后研究员，成为血液恶性肿瘤和干细胞移植研究所的Pichiorri实验室的一个组成部分。

我们的长期目标是阐明骨髓瘤发展的分子机制和治疗后获得性抵抗机制的颠覆。因此，成功的候选人将参与与骨髓瘤发展相关的微环境、遗传和表观遗传变化的研究，包括但不限于糖尿病易患癌症和使用不同骨髓瘤小鼠模型、原始样本和体内相关研究的小的非编码RNA。在该部门的大力支持下，其主要目标之一是促进发现治疗骨髓瘤的新治疗靶点，并制定具体的第一阶段试验，以弥合基础科学与临床实践之间的差距。

英文原文：

Postdoctoral Fellow - Molecular Mechanisms of Myeloma

· City of Hope

· Location: Duarte, CA

· Job Number: 7057370

· Posting Date: May 20, 2019

Job Description

The Beckman Research Institute of City of Hope is looking for a talented Postdoctoral Fellow to become an integral part of Pichiorri Lab, within the Division of Hematologic Malignancies and Stem Cell Transplantation Institute.

Our long-term goal is to elucidate the molecular mechanism(s) underlying the development of myeloma and the insurgence of mechanisms of acquired resistance upon treatments. As such, the successful candidate will participate in the investigation of microenvironmental, genetic and epigenetic changes associated with myeloma development, including but not limited to diabetes predisposition to cancer and small non coding RNAs using different myeloma mouse models, primary samples and in vivo correlative studies. With strong support from the department, one of the main goals is to foster the discovery of novel therapeutic targets for the treatment of myeloma and to develop specific Phase 1 trial for bridging the gap between basic science and clinical practice.

Basic education, experience and skills required for consideration:

A Ph.D. degree in biology, life or biomedical sciences, or a related discipline is required;

Experience in recombinant protein production for cellular drug high throughput screening, protein purification and protein-protein interaction;

Experience in DNA damage;

In vitro cell culture: human and mouse cells, leukemia, myeloma, cell transfections and drugs treatments;

Experience in mouse bone marrow transplant (BMT) and engraftment studies;

Experience with any of the animal cancer models: leukemia/myeloma or solid tumors (breast, prostate, liver);

Experience in multicolor flow cytometry, RNA, DNA isolation and preparation, QRT-PCR, Elisa assay, Western blot, IP techniques, Cloning and Luciferase assay.

Additional Information:

For more information about Dr. Pichiorri’s research, please visit: https://www.cityofhope.org/people/pichiorri-flavia.

City of Hope is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.

City of Hope is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.