招聘简介：

密歇根州安阿伯大学癌症药物发现医学化学博士后研究员

·密歇根大学

·地点：密歇根州安娜堡

·工作编号：7057223

·发布日期：2019年5月7日

·申请截止日期：2019年7月6日

职位描述

职位描述

在密歇根大学安娜堡托马兹·切尔皮奇教授的实验室中，可以获得博士后职位，以开发针对癌症治疗的小分子抑制剂。我们正在寻找积极性很高的合成有机化学家和药物化学家加入一个全面的药物发现计划。Cierpicki博士的实验室正在进行高度跨学科的研究，重点是新型抗癌药物的临床前开发，包括药物化学、结构生物学、生化和生物物理分析、生物和动物研究。我们有一支强大的合成化学家团队来支持我们的药物发现工作。成功的候选人将参与设计和合成作为潜在抗癌剂的小分子抑制剂靶向蛋白质，主要关注与癌症相关的靶向蛋白质-蛋白质相互作用的杂环化合物的合成。其职责将包括设计和合成现有引线的新类似物，以开发生物活性化合物，用于测试癌细胞和动物。候选人必须独立设计合成路线，解决具有挑战性的合成问题，有效合成目标分子，包括多步合成。

英文原文：

Postdoctoral Fellow in Medicinal Chemistry for Cancer Drug Discovery University of Michigan, Ann Arbor

· University of Michigan

· Location: Ann Arbor, MI

· Job Number: 7057223

· Posting Date: May 7, 2019

· Application Deadline: Jul 6, 2019

Job Description

Job Description

Postdoctoral position is available in the laboratory of Prof. Tomasz Cierpicki, University of Michigan, Ann Arbor, to develop small molecule inhibitors for targeted therapies in cancer. We are seeking for highly motivated synthetic organic chemists and medicinal chemists to join a comprehensive drug discovery program. Dr. Cierpicki’s lab. is conducting highly interdisciplinary research focused on pre-clinical development of novel anti-cancer drugs, which covers medicinal chemistry, structural biology, biochemical and biophysical assays, biological and animal studies. We have a strong team of synthetic chemists to support our drug-discovery efforts. The successful candidate will be involved in designing and synthesis of small molecule inhibitors targeting proteins as potential anti-cancer agents with a major focus on synthesis of heterocyclic compounds targeting protein-protein interactions relevant to cancer. The duties will include design and synthesis of new analogues of existing leads to develop biologically active compounds for testing in cancer cells and animals. The candidate must be independent in designing synthetic routes, solving challenging synthetic problems, efficient in synthesizing targeted molecules, including multi-step synthesis.

Requirements

Applicant must have PhD in synthetic organic chemistry or medicinal chemistry and be a first author on at least 2-3 publications. This position requires extensive experience in designing synthetic routes for new classes of compounds, solving challenging synthetic problems, SAR analysis. Applicant needs an expertise in using HPLC, NMR and MS for organic chemistry applications. Excellent oral and written communication skills in English are required.

How to apply

Please submit cover letter, CV, and contact information for 2-3 references combined into one PDF file by e-mail to: tomaszc@umich.edu

Contact:

Tomasz Cierpicki, PhD, Associate Professor

Department of Pathology, University of Michigan

Ann Arbor, MI, 48109, USA

https://www.pathology.med.umich.edu/index.php?t=page&id=1473

e-mail: tomaszc@umich.edu

Relevant publications:

1. Borkin, D. et al, Complexity of blocking bivalent protein-protein interactions: development of a highly potent

inhibitor of the menin-Mixed Lineage Leukemia interaction, J. Med. Chem. 2018, 61(11): 4832.

2. Borkin D. et al, Property Focused Structure-Based Optimization of Small Molecule Inhibitors of the Protein-

Protein Interaction between Menin and Mixed Lineage Leukemia (MLL). J Med Chem. 2016, 59(3): 892-913.

3. Borkin, D. et al., Pharmacologic inhibition of the menin-MLL interaction blocks progression of MLL leukemia in

vivo, Cancer Cell, 2015, 27 (4), 589-602.