招聘简介：

·莫菲特癌症中心和研究所

·地点：佛罗里达州坦帕市

职位描述

H. Lee Moffitt癌症中心和研究所为转化肺癌研究的博士后学者开设了一个研讨会。 Haura实验室追求跨学科方法，涵盖蛋白质组学，化学生物学，转化医学，分子生物学，生物化学和生物信息学，以表征癌症信号网络的系统级视图。特别强调整合功能蛋白质组学技术，例如，化学和磷酸化蛋白质组学，剖析药物作用和癌症生物学的潜在机制。见http://labpages.moffitt.org/haurae/Home.html

我们正在寻找一位具有跨学科技能的科学家，他有兴趣使用邻近连接测定（PLA）技术从事与蛋白质复合物注释相关的项目（Smith，Science Signaling，2015; Smith，Clinical Cancer Research，2017）。该项目将包括使用人肺癌组织的现有EGFR和MET邻近测定的临床验证研究。该候选人将确定我们机构的肺癌标本中EGFR PLA的发生率，并使用由试验相关的肺癌标本组成的多个外部队列研究EGFR PLA与EGFR定向治疗反应的关联。

英文原文：

· Moffitt Cancer Center and Research Institute

· Location: Tampa, FL

Job Description

The H. Lee Moffitt Cancer Center and Research Institute has an opening for a postdoctoral scholar in translational lung cancer research. The Haura lab pursues an interdisciplinary approach spanning proteomics, chemical biology, translational medicine, molecular biology, biochemistry, and bioinformatics to characterize systems level views of cancer signaling networks. Particular emphasis is given to integrating functional proteomics technologies, e.g. chemical and phosphoproteomics, to dissect the underlying mechanism of drug action and cancer biology. See http://labpages.moffitt.org/haurae/Home.html

We are looking for a scientist with a cross-disciplinary skill set who is interested in working on projects related to protein complex annotation using proximity ligation assay (PLA) technology (Smith, Science Signaling, 2015; Smith, Clinical Cancer Research, 2017). The project will consist of clinical validation studies of existing EGFR and MET proximity assays using human lung cancer tissues. The candidate will define the incidence of EGFR PLA in lung cancer specimens from our institution and investigate the association of EGFR PLA with response to EGFR-directed therapies using multiple external cohorts, consisting of trial-associated lung cancer specimens.

The successful candidate must hold a PhD in cancer biology (or related discipline) and have extensive experience with immunohistochemistry, analytical microscopy, human subjects research and modern molecular biology techniques. A firm understanding of predictive biomarker strategies, intracellular signaling and basic statistical concepts will be highly beneficial. Candidates with experience in cancer pathology and/or tissue based imaging will be given priority. The position requires the ability to operate in an independent manner with limited supervision and to lead collaborative efforts across multiple disciplines within Moffitt and external industry collaborators. Strong written and verbal communication skills will be required. Opportunities for travel to relevant conferences, grant writing and mentoring are available.

Interested candidates should send CV, cover letter describing research interests and 2-3 references to Eric.Haura@moffitt.org.