招聘简介：

博士后研究员 - 血液学 - 肿瘤学和免疫学

·希望之城

·地点：加利福尼亚州杜阿尔特

·工作号码：7057373

·发布日期：2019年5月20日

·申请截止日期：开放至填写

职位描述

希望之城贝克曼研究所正在寻找一位才华横溢，积极进取的博士后研究员，该系在生物系统生物学系新建的Srividya Swaminathan博士实验室。该实验室专注于了解B-和T-淋巴恶性肿瘤周围的免疫微环境。通过比较正常和恶性淋巴细胞生成期间的全球免疫景观，将鉴定出特异性靶向恶性淋巴细胞的免疫疗法。研究范围包括血液学，肿瘤学和免疫肿瘤学。用淋巴恶性肿瘤的转基因小鼠模型，原代人淋巴癌细胞，人源化小鼠，研究恶性淋巴细胞和宿主免疫之间相互作用的移植模型，基因编辑，经典分子和细胞生物学以及致癌信号转导进行实验。

英文原文：

Postdoctoral Fellow - Hematology-Oncology and Immunology

· City of Hope

· Location: Duarte, CA

· Job Number: 7057373

· Posting Date: May 20, 2019

· Application Deadline: Open Until Filled

Job Description

The Beckman Research Institute of City of Hope is looking for a talented and motivated Postdoctoral Fellow in the newly established laboratory of Dr. Srividya Swaminathan in the Department of Systems Biology. The lab is focused on understanding the immune microenvironment surrounding B- and T- lymphoid malignancies. By comparing the global immune landscape during normal and malignant lymphopoiesis, immunotherapies will be identified that specifically target malignant lymphocytes. Research spans Hematology, Oncology, and Immuno-Oncology. Experiments are performed with transgenic mouse models of lymphoid malignancies, primary human lymphoid cancer cells, humanized mice, transplantation models to study interactions between malignant lymphocytes and host immunity, gene editing, classical molecular and cell biology, and oncogenic signal transduction.

Methods that will be extensively utilized but not limited to are:

Immune profiling (flow cytometry, mass cytometry (CyTOF), CIBERSORT)

In vivo assays (mouse genetics, intravenous and intrafemoral transplantation assays, humanized mouse models of lymphoma, pre-clinical testing of cell-based and other immunotherapies in xenotransplantation models, bioluminescence imaging)

Molecular biology and biochemistry (retroviral/lentiviral transduction, molecular cloning, RNA/DNA sequencing, qPCR, immunoblotting, immunofluorescence, luminex)

Basic education, experience and skills required for consideration:

PhD in Immunology, Cell, Molecular biology, life or biomedical sciences, or a related discipline is required;

Enthusiasm for science, and willingness to think beyond established concepts;

Experience with flow cytometry, and prior experience with handling mice and performing in vivo procedures (strongly desired);

Enthusiasm to learn new experimental and computational data analysis tools;

Highly independent with excellent organizational skills;

Collaborative team player.

Additional Information:

Application should include Curriculum Vitae and coordinates of three scientific mentors;

Application should include a cover letter highlighting research interests, a brief statement explaining how past research ties in with the goals of this laboratory, and future career plans;

For more information about Dr. Swaminathan’s research please click here: https://www.cityofhope.org/research/systems-biology/systems-biology-research-labs/srividya-swaminathan-lab;

Recent work: While working as a Postdoctoral Fellow and then as an Instructor at Stanford University, Dr. Swaminathan investigated how oncogenes modulate anti-tumor immune surveillance (Swaminathan et al., Nature Communications, in revision; bioRxiv, 2018: https://www.biorxiv.org/content/10.1101/503086v1; JITC,2018: https://jitc.biomedcentral.com/articles/10.1186/s40425-018-0431-x). Using CyTOF in a primary mouse model of MYC-driven T cell neoplasia, she mechanistically demonstrated the direct and reversible suppression of natural killer (NK) cells by the MYC oncogene. Her studies provide a strong rationale for developing NK cells as a therapy against MYC-driven, and other oncogene-driven lymphoid malignancies that rely on MYC (Swaminathan et al., Nature Communications, in revision; bioRxiv, 2018: https://www.biorxiv.org/content/10.1101/503086v1. Dr. Swaminathan’s laboratory will utilize her extensive research experience in normal and malignant lymphocyte biology (Nature Immunology, 2015: https://www.nature.com/articles/ni.3160; Nature Medicine, 2013: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3954721/), in identifying the vulnerabilities specific to malignant lymphocytes. Her laboratory is funded by the Leukemia and Lymphoma Society (LLS): https://www.lls.org/content/induction-of-immunological-memory-to-target-myc-driven-lymphomas, the American Society of Hematology (ASH): https://www.hematology.org/Awards/Award-Recipients/2119.aspx, and City of Hope.

City of Hope is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.

City of Hope is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.