招聘简介：

研究科学家 - Kapil N. Bhalla博士的实验室

·德克萨斯大学MD安德森癌症中心

·地点：德克萨斯州休斯顿

·工作号码：7057422（参考号：127265）

·发布日期：2019年5月24日

·申请截止日期：开放至填写

职位描述

研究科学家 - Kapil N. Bhalla博士的实验室

Kapil N. Bhalla博士目前正在寻找一名高级研究科学家，负责在NIH资助的实验室进行研究。本实验室基础和转化研究的重点包括与表观遗传机制相关的生物学和发育疗法，包括组蛋白去乙酰化酶，甲基转移酶和去甲基化酶，BET蛋白，以及热休克蛋白及其癌症相关客户蛋白调节细胞的伴侣生物学。人白血病干/祖细胞的生长，分化和存活。合格的候选人必须拥有博士学位。在生物学，生物科学或相关生命科学领域，以及对癌症研究的浓厚兴趣和经验。候选人必须在与Bhalla博士实验室研究重点相关的领域完成至少3年的博士后研究。合格的候选人必须有能力在设计和进行实验室研究时进行故障排除。利用涉及基因转染的分子研究，通过RNA-Seq分析基因表达，QPCR，免疫印迹和流式细胞术，以及染色质免疫沉淀研究，使用2D凝胶评估蛋白质生物化学和酵母双杂交系统的经验和出版物，和组织培养技术是必需的。非常需要具有利用CRISPR技术进行基因编辑和利用共聚焦显微镜进行分子成像的能力。还需要在异种移植和基因工程的癌症和/或白血病动物模型以及共聚焦显微镜中的经验。提供优秀的研究环境，新的实验室和核心设施。

英文原文：

Research Scientist - Dr. Kapil N. Bhalla's Laboratory

· University of Texas MD Anderson Cancer Center

· Location: Houston, TX

· Job Number: 7057422 (Ref #: 127265)

· Posting Date: May 24, 2019

· Application Deadline: Open Until Filled

Job Description

Research Scientist - Dr. Kapil N. Bhalla's Laboratory

Dr. Kapil N. Bhalla is currently seeking a Senior Research Scientist who will be responsible for conducting research in his NIH-funded laboratory. The focus of the basic and translational research in this laboratory includes the biology and developmental therapeutics related to epigenetic mechanisms involving histone deacetylases, methyltransferases and demethylases, BET proteins, as well as the chaperone biology of heat shock proteins and their cancer relevant client proteins regulating cell growth, differentiation and survival of the human leukemia stem/progenitor cells. The qualified candidate must possess a Ph.D. in Biology, Biological Science or related Life Sciences, and a keen interest and experience in cancer research. The candidate must have completed at least a 3 year Post-doctoral fellowship in an area relevant to the focus of research in Dr. Bhalla’s laboratory. The qualified candidate must have the ability to troubleshoot in the design and conduct of laboratory studies. Experience and publications utilizing molecular studies involving gene transfection, analysis of gene expression through RNA-Seq, QPCR, immunoblots and flow cytometry, as well as in chromatin immunoprecipitation studies, evaluation of protein biochemistry with 2D gels and the yeast-two-hybrid system, and tissue culture techniques is required. Experience in the ability to utilize CRISPR technology for gene editing and to utilize confocal microscopy for molecular imaging is highly desired. Experience in xenograft and genetically-engineered animal models of cancer and/or leukemia, and confocal microscopy is also desired. An outstanding research environment, new laboratory and core facilities are provided.

KEY FUNCTIONS

Research Design and implementation

Plans, organizes, coordinates, directs and conducts scientific research projects. Develops and maintains standard procedures and protocols to ensure the quality and integrity of the procedures performed. Coordinates with other investigators to provide appropriate support on analytical techniques. Maintains detailed experimental records, evaluates resulting research data, and presents findings to physicians and/or professional groups.

Data Analysis

Analyzes and evaluates research data and revises techniques and approaches to work problems. Works with the Principal Investigator on projects in the area of biomarker development and leukemia biology. Participates in adopting new techniques and learning new skills to enhance research efforts.

Lab Development/Publications

Supervises, mentors, and counsels trainees and other laboratory personnel with respect to proper laboratory techniques, the use of laboratory equipment and safety procedures. Publications/Manuscripts and Presentations. Contributes to manuscripts and prepares documents for publication. Compiles, writes, and submits reports to superior. Presents results at national meetings.

EDUCATION

Required: PhD in one of the natural sciences or related field or Medical degree.

EXPERIENCE

Required: With PhD, no experience required. With Medical degree, two years of experience in experimental or scientific work.

Preferred: With PhD must have completed at least a 3 year Post-doctoral fellowship in an area relevant to the focus of research in Dr. Bhalla's laboratory.