招聘简介：

化学生物学和有机/药物化学博士后研究员

·圣母大学

·地点：巴黎圣母院，IN

·工作号码：7057647

·发布日期：2019年6月10日

·申请截止日期：开放至填写

职位描述

圣母大学化学与生物化学系Juan Del Valle教授的实验室目前正在接受两个公开博士后职位的申请。

第一个是化学生物学领域，研究项目侧重于蛋白质 - 蛋白质相互作用抑制剂和ER应激反应途径的生物学评估和表征。这些靶标的调节剂将用于治疗癌症和神经退行性疾病。职责包括重组蛋白表达/纯化，体外生化测定的开发，以及细胞测定中优化抑制剂的评估。

第二个开放职位是有机/药物化学领域。职责包括生物活性肽模拟物和小分子的设计和多步合成，以及基于结构的优化以靶向蛋白质 - 蛋白质相互作用。

考生必须拥有博士学位。在化学，生物学或相关领域，并具有良好的书面和口头沟通技巧。最近将获得高度积极的博士学位。毕业生在以下一个或多个领域具有额外经验：药物设计，复杂分子合成，分子药理学和结构生物学。在我们的实验室参与其他正在进行的跨学科工作将是感兴趣的候选人的选择。

申请人应提交一份说明感兴趣的职位的求职信，完整的简历，简要的博士研究摘要，以及三个参考jdelvalle@nd.edu的联系信息。申请审查将立即开始，并一直持续到职位填补。请访问delvallelab.weebly.com获取更多信息。

英文原文：

Postdoctoral Fellowships in Chemical Biology and Organic/Medicinal Chemistry

· University of Notre Dame

· Location: Notre Dame, IN

· Job Number: 7057647

· Posting Date: Jun 10, 2019

· Application Deadline: Open Until Filled

Job Description

The laboratory of Prof. Juan Del Valle in the Department of Chemistry & Biochemistry at the University of Notre Dame is currently accepting applications for two open Postdoctoral positions.

The first is in the area of Chemical Biology, with research projects focused on the biological evaluation and characterization of inhibitors of protein-protein interactions and ER stress response pathways. Modulators of these targets will be applied to the treatment of cancer and neurodegenerative disorders. Duties will include recombinant protein expression/purification, development of in vitro biochemical assays, and evaluation of optimized inhibitors in cellular assays.

The second open position is in the area of Organic/Medicinal Chemistry. Duties will include the design and multi-step synthesis of biologically active peptidomimetics and small molecules, and structure-based optimization to target protein-protein interactions.

Candidates must have a Ph.D. in Chemistry, Biology, or a related field, and possess excellent written and oral communication skills. Priority will be given to highly motivated, recent Ph.D. graduates with additional experience in one or more of the following areas: drug design, complex molecule synthesis, molecular pharmacology, and structural biology. Involvement in other ongoing interdisciplinary efforts in our laboratory will be an option for interested candidates.

Applicants should submit a cover letter indicating the position of interest, complete CV, brief doctoral research summary, and contact information for three references to jdelvalle@nd.edu. Review of applications will begin immediately and continue until the positions are filled. Please visit delvallelab.weebly.com for more information.

The University of Notre Dame has exceptional facilities for conducting biomedical research, including state-of-the-art NMR, mass spectrometry, crystallography, microscopy, genomics, and imaging facilities, among others. The successful candidate will have access to an array of resources throughout the College of Science and in the Warren Family Research Center for Drug Discovery and Development, which includes Biological Screening, Chemical Synthesis, and Computer-aided Molecular Design Core Facilities. The Del Valle laboratory and the Warren Center are housed in recently completed McCourtney Hall, a 220,000 square foot building dedicated to research in the molecular sciences and engineering.

Postdoctoral Scholars at the University of Notre Dame enjoy a highly competitive compensation and benefits package that includes a retirement plan, medical/dental/vision insurance, paid-time-off, parental leave, and educational reimbursement, among other benefits. The University of Notre Dame seeks to attract, develop, and retain the highest quality faculty, staff and administration. The University is an Equal Opportunity Employee and is committed to building a culturally diverse workplace.