招聘简介：

密歇根大学安娜堡分校癌症药物发现药物化学博士后研究员

·密歇根大学

·地点：密歇根州安娜堡

·工作号码：7057223

·发布日期：2019年5月7日

·申请截止日期：2019年7月6日

职位描述

职位描述

博士后职位可在密歇根大学安娜堡分校的Tomasz Cierpicki教授的实验室中获得，以开发用于癌症靶向治疗的小分子抑制剂。我们正在寻找具有高度积极性的合成有机化学家和药物化学家加入全面的药物发现计划。 Cierpicki博士的实验室。正在进行高度跨学科的研究，重点是新型抗癌药物的临床前开发，包括药物化学，结构生物学，生物化学和生物物理分析，生物学和动物研究。我们拥有一支强大的合成化学家团队，以支持我们的药物发现工作。成功的候选人将参与设计和合成靶向蛋白质的小分子抑制剂作为潜在的抗癌剂，主要关注合成靶向与癌症相关的蛋白质 - 蛋白质相互作用的杂环化合物。职责包括设计和合成现有线索的新类似物，以开发用于癌细胞和动物测试的生物活性化合物。候选人必须独立设计合成路线，解决具有挑战性的合成问题，有效合成目标分子，包括多步合成。

英文原文：

Postdoctoral Fellow in Medicinal Chemistry for Cancer Drug Discovery University of Michigan, Ann Arbor

· University of Michigan

· Location: Ann Arbor, MI

· Job Number: 7057223

· Posting Date: May 7, 2019

· Application Deadline: Jul 6, 2019

Job Description

Job Description

Postdoctoral position is available in the laboratory of Prof. Tomasz Cierpicki, University of Michigan, Ann Arbor, to develop small molecule inhibitors for targeted therapies in cancer. We are seeking for highly motivated synthetic organic chemists and medicinal chemists to join a comprehensive drug discovery program. Dr. Cierpicki’s lab. is conducting highly interdisciplinary research focused on pre-clinical development of novel anti-cancer drugs, which covers medicinal chemistry, structural biology, biochemical and biophysical assays, biological and animal studies. We have a strong team of synthetic chemists to support our drug-discovery efforts. The successful candidate will be involved in designing and synthesis of small molecule inhibitors targeting proteins as potential anti-cancer agents with a major focus on synthesis of heterocyclic compounds targeting protein-protein interactions relevant to cancer. The duties will include design and synthesis of new analogues of existing leads to develop biologically active compounds for testing in cancer cells and animals. The candidate must be independent in designing synthetic routes, solving challenging synthetic problems, efficient in synthesizing targeted molecules, including multi-step synthesis.

Requirements

Applicant must have PhD in synthetic organic chemistry or medicinal chemistry and be a first author on at least 2-3 publications. This position requires extensive experience in designing synthetic routes for new classes of compounds, solving challenging synthetic problems, SAR analysis. Applicant needs an expertise in using HPLC, NMR and MS for organic chemistry applications. Excellent oral and written communication skills in English are required.

How to apply

Please submit cover letter, CV, and contact information for 2-3 references combined into one PDF file by e-mail to: tomaszc@umich.edu

Contact:

Tomasz Cierpicki, PhD, Associate Professor

Department of Pathology, University of Michigan

Ann Arbor, MI, 48109, USA

https://www.pathology.med.umich.edu/index.php?t=page&id=1473

e-mail: tomaszc@umich.edu

Relevant publications:

1. Borkin, D. et al, Complexity of blocking bivalent protein-protein interactions: development of a highly potent

inhibitor of the menin-Mixed Lineage Leukemia interaction, J. Med. Chem. 2018, 61(11): 4832.

2. Borkin D. et al, Property Focused Structure-Based Optimization of Small Molecule Inhibitors of the Protein-

Protein Interaction between Menin and Mixed Lineage Leukemia (MLL). J Med Chem. 2016, 59(3): 892-913.

3. Borkin, D. et al., Pharmacologic inhibition of the menin-MLL interaction blocks progression of MLL leukemia in

vivo, Cancer Cell, 2015, 27 (4), 589-602.