招聘简介：

博士后助理 - 分子与人类遗传学

·贝勒医学院

·地点：德克萨斯州休斯顿

·工作号码：7057719（参考号：312026KP）

·发布日期：2019年6月13日

·申请截止日期：开放至填写

职位描述

博士后助理职位可在对动物发育和人类疾病中糖基化和去糖基化作用感兴趣的实验室中获得。该实验室利用细胞培养，果蝇和小鼠遗传学来鉴定和表征人类疾病基因的遗传修饰因子，希望能够揭示疾病病理生理学并建立新的治疗靶点。实验室工作人员与碳水化合物生物化学专家密切合作。该实验室已经报道了一种称为Alagille综合征（ALGS; OMIM 118450）的发育障碍的小鼠模型，并且在该ALGS模型中鉴定了称为Poglut1的糖基转移酶作为胆管表型的显性遗传抑制因子（Thakurdas等，Hepatology，2016）。还确定了转录因子作为疾病表型的显性修饰因子，其表达也与人类患者的肝病严重程度有很强的相关性（未发表的数据）。

·在这些观察的基础上，博士后人员将检查参与ALGS肝脏异常的遗传和转录网络，并将研究这些观察结果对于开发这种疾病的疗法的潜在效用。这些研究可能为疾病背景下的正常胆道发育和胆道修复提供基本见解。

英文原文：

Postdoctoral Associate - Molecular and Human Genetics

· Baylor College of Medicine

· Location: Houston, TX

· Job Number: 7057719 (Ref #: 312026KP)

· Posting Date: Jun 13, 2019

· Application Deadline: Open Until Filled

Job Description

A Postdoctoral Associate position is available in a laboratory interested in the role of glycosylation and deglycosylation in animal development and human disease. The lab uses cell culture, Drosophila and mouse genetics to identify and characterize genetic modifiers of human disease genes, in hopes of shedding light on disease pathophysiology and establishing new therapeutic targets. The lab staff closely collaborate with experts in carbohydrate biochemistry. The lab has reported a mouse model for a developmental disorder called Alagille syndrome (ALGS; OMIM 118450), and identified a glycosyltransferase called Poglut1 as a dominant genetic suppressor of the biliary phenotypes in this ALGS model (Thakurdas et al, Hepatology, 2016). Have also identified a transcription factor as a dominant modifier of the disease phenotypes, whose expression also shows a strong correlation with liver disease severity in human patients (unpublished data).

· Building on these observations, the postdoctoral associate will examine the genetic and transcriptional network involved in ALGS liver abnormalities and will examine the potential utility of these observations for developing therapies for this disease. These studies are likely to provide fundamental insights into normal biliary development and biliary repair in disease contexts.

Required: PhD in biomedical science or equivalent

· Experience in mouse genetics and mammalian cell culture is essential.

· Expertise in molecular biology and biochemistry is highly desired.

· The ideal candidate will be a highly motivated and have a strong publication record.