招聘简介：

·贝勒医学院

·地点：德克萨斯州休斯顿

·工作号码：7057704（参考号：208172SM）

·发布日期：2019年6月13日

·申请截止日期：开放至填写

职位描述

候选人应该获得生物医学科学博士学位，重点是癌症免疫学和/或肿瘤微环境。此外，强大的技术技能，计算机和数学能力，以及组织和判断技能是必不可少的。该项目的重点是用嵌合抗原受体T细胞进行癌症免疫治疗。该项目将涉及细胞生物学，分子生物学和免疫学领域的实验。使用的技术包括但不限于：

·从血液样品中分离人细胞，细胞分选，鼠和人细胞系的培养，用质粒和/或病毒载体转导细胞。

·Elispot检测; FACS分析;细胞毒性测定

·DNA / RNA提取，PCR，克隆，Western印迹分析

·动物实验评估CAR T细胞对异种移植小鼠模型的安全性和抗肿瘤作用此外，还需要独立规划实验，撰写手稿，摘要和授权申请，以及指导学生。

需要：

·生物医学科学或相关专业博士学位。

·在细胞生物学，分子生物学和免疫学领域的经验。

英文原文：

· Baylor College of Medicine

· Location: Houston, TX

· Job Number: 7057704 (Ref #: 208172SM)

· Posting Date: Jun 13, 2019

· Application Deadline: Open Until Filled

Job Description

The candidate should have a received a PhD in biomedical sciences, with focus on cancer immunology and/or the tumor microenvironment. In addition, strong technical skills, computer and math abilities, as well as organizational and judgment skills are essential. The project is focused on cancer immunotherapy with Chimeric Antigen Receptor T cells. The project will involve experiments in the areas of cell biology, molecular biology, and immunology. Techniques used include but are not limited to:

· Isolation of human cells from blood samples, cell sorting, culture of murine and human cell lines, transduction of cells with plasmids and/or viral vector.

· Elispot assays; FACS analysis; Cytotoxicity assays

· DNA/RNA extraction, PCR, cloning, Western blot analysis

· Animal experiments to evaluate the safety and antitumor effects of CAR T cells on Xenograft mouse models In addition, independent planning of experiments, writing manuscripts, abstracts, and grant applications, and mentoring students is required.

Required:

· PhD in biomedical sciences or related.

· Experience in the areas of cell biology, molecular biology, and immunology.