招聘简介：

生物医学科学：密歇根大学癌症生物学博士后研究员，安娜堡

·密歇根大学

·地点：密歇根州安娜堡

·工作编号：7057183

·发布日期：2019年5月2日

·申请截止日期：2019年7月2日

工作描述

说明：

在密歇根大学安娜堡分校Jolanta Grembecka教授实验室获得生物医学科学博士后职位，以开展跨学科项目，研究小分子在体外和体内癌症模型中的作用，并采用遗传方法进行目标验证研究。我们正在寻找一位积极进取的博士后，在癌症细胞生物学方面拥有丰富的经验。本研究的重点是评价新型小分子阻断肿瘤表观遗传蛋白的活性和作用机制。这个职位需要在细胞生物学和分子生物学技术方面的专业知识，包括PCR，qrt-pcr，western blotting，co-immunosegration，chip，chipseq，流式细胞术，荧光显微镜，免疫染色。有转基因小鼠和异种移植癌模型等动物的工作经验者优先。成功的候选人将是一个跨学科团队的一部分，该团队专注于新型抗癌药物候选人的开发和临床前评估。

英文原文：

Biomedical Science: Postdoctoral Fellow in Cancer Biology, University of Michigan, Ann Arbor

· University of Michigan

· Location: Ann Arbor, MI

· Job Number: 7057183

· Posting Date: May 2, 2019

· Application Deadline: Jul 2, 2019

Job Description

Description:

Postdoctoral position in biomedical science is available in Prof. Jolanta Grembecka laboratory, University of Michigan, Ann Arbor, to carry out an interdisciplinary project to study the effect of small molecules in in vitro and in vivo models of cancers and to pursue target validation studies using genetic approaches. We are seeking for a highly motivated postdoctoral fellow with extensive experience in cancer cell biology. The research will be focused on evaluation of the activity and the mechanism of action of novel small molecules blocking epigenetic proteins in cancer. This position requires the expertise in cell biology and molecular biology techniques, including PCR, qRT-PCR, Western Blotting, co-Immunoprecipitation, ChIP, ChIPSeq, flow cytometry, fluorescence microscopy, immunostaining. Prior work experience with animals such as transgenic mice and xenograft models of cancer would be desired. Successful candidate will be a part of an interdisciplinary team focused on development and pre-clinical evaluation of novel anti-cancer drug candidates.

Requirements:

Applicant must have PhD in biology or related field. The candidates must be a first author on at least 2-3 publications. This position requires extensive experience in cell and molecular biology techniques. Furthermore, excellent oral and written communication skills in English are required as well as the ability to conduct independent scientific investigations.

How to apply:

Please submit cover letter, CV, and contact information for 2-3 references combined into one PDF file by e-mail to: jolantag@umich.edu.

Contact:

Jolanta Grembecka, PhD, Associate Professor

Department of Pathology, University of Michigan

Ann Arbor, MI, 48109, USA

https://www.pathology.med.umich.edu/index.php?t=page&id=1473

e-mail: jolantag@umich.edu

Relevant publications:

1. Borkin, D. et al., Grembecka, J., Pharmacologic inhibition of the menin-MLL interaction blocks progression of

MLL leukemia in vivo, Cancer Cell, 2015, 27 (4), 589-602.

2. He S, et; al., Grembecka J., Menin-MLL inhibitors block oncogenic transformation by MLL fusion proteins in a

fusion partner independent manner. Leukemia. 2016 Feb;30(2):508-13.

3. Kempinska K, et al, Grembecka J: Pharmacologic inhibition of the menin-MLL interaction leads to

transcriptional repression of PEG10 and blocks hepatocellular carcinoma. Mol Cancer Ther: 2018 Jan;17(1):26-

38.