招聘简介：

博士后研究员

·德州大学安德森癌症中心

·地点：德克萨斯州休斯顿

·工作编号：7058190

·发布日期：2019年6月25日

·申请截止日期：开放至填写

工作描述

我们正在寻找一个在肿瘤免疫学和癌细胞生物学方面具有技术专长的创新性和积极性的人来进行一个雄心勃勃的项目，目标是白血病细胞中的免疫检测点蛋白。理想的候选人将拥有生命科学博士学位，如细胞生物学或分子生物学，具有研究经验，并在细胞生物学、肿瘤免疫学和与肿瘤间质相互作用有关的信号传导过程方面拥有优秀的知识库。有白血病、T细胞和NK细胞原代培养、定量测量RNA表达、流式细胞术、人源化单克隆抗体、大数据分析和/或使用动物模型的经验者优先。申请人应享受为学生和其他同事提供培训的角色，并应在大型研究小组内开放进行科学合作。应聘者应具备良好的书面和口头（英语）沟通能力。

英文原文：

Postdoctoral Fellow

· The University of Texas M. D. Anderson Cancer Center

· Location: Houston, TX

· Job Number: 7058190

· Posting Date: Jun 25, 2019

· Application Deadline: Open Until Filled

Job Description

We are looking for an innovative and motivated individual with technical expertise in tumor immunology and cancer cell biology to conduct a highly ambitious project targeting immune-checkpoint proteins in leukemia cells. The ideal candidate will possess a PhD degree in a life science, like cellular or molecular biology, with research experience and an excellent knowledge-base in cell biology, tumor immunology, and signaling process as they relate to tumor-stroma interactions. Experience in leukemia, primary cell culture of T cells and NK cells, the quantitative measurement of RNA expression, flow cytometry, humanized monoclonal antibodies, big data analysis, and/or the use of animal models would be a plus. The applicant should enjoy providing a training role for students and other coworkers, and should be open to scientific collaboration within a large research group. The candidate should possess excellent written and spoken (English) communication skills.

The task: Development of monoclonal antibodies to target immune checkpoint proteins in leukemia cells through series of immune cell mediated cytotoxicity assays such as chromium release assay, apoptosis and cell death assays. The ultimate goal of this project is to develop therapeutic (chimeric/fully humanized) antibodies to target immune checkpoint proteins that are overexpressed in leukemia cells. The postdoctoral fellow will collaborate with related investigators in an interdisciplinary research project that involves basic cell culture, flow cytometry/sorting, immune cell mediated cytotoxicity assays, DNA/RNA isolation/analysis, and the use of immuno-competent/deficient mouse models. The postdoctoral fellow will present relevant scientific findings at project meetings, National and international conferences, and via publication in top-tier scientific publications.

Interested candidates should email their CV to Dr. Batula at: vbattula@mdanderson.org with a subject line stating “Postdoctoral position-2 in your laboratory”