美国康涅狄格大学医学院免疫学/细胞生物学/心血管/生物医学工程方向博士后招聘

NIH-supported postdoc fellows in Leukocyte Biology and Immunology at the University of Connecticut School of Medicine (UConn Health)

Our laboratory is looking for multiple motivated postdoctoral fellows to study integrin activation and leukocyte trafficking in inflammatory diseases using advanced microscopy, such as super-resolution microscopy, high-resolution live-cell imaging, and intravital microscopy. Our current research directions include:

1. The auto-inhibitory in-cis interaction of integrin and their ligands.

2. The roles and mechanism of integrin activation and clustering using super-resolution microscopy.

3. Pharmacology test of drugs targeting integrins in vitro and in disease models (myocardial ischemia-reperfusion injury)

4. High-throughput screening of drugs inhibiting integrin activation and inflammation.

5. Monitoring of leukocyte dynamics in diseases using intravital microscopy and in vivo flow cytometry (IVFC).

We work on primary human leukocytes, leukocyte-like cell lines, and gene-edited mice to answer questions regarding integrin activation and leukocyte trafficking. Multiple advanced microscopy, from single-molecular level super-resolution microscopy to physiological-relevant intravital microscopy, will be used.

The PI is a faculty member (https://facultydirectory.uchc.edu/profile?profileId=Fan-Zhichao) of the Department of Immunology at UConn Health (https://health.uconn.edu/immunology/). This is an exciting research environment to cultivate new research ideas and opportunities. The PI has received an R01 award from NIH and a startup fund from UConn Health to support our research. The candidate will receive excellent guidance on scientific research as well as career development (grants, awards, conferences, etc.).

Qualified applicants should have a Ph.D. degree in Cell Biology, Immunology, Biomedical Engineering, Cardiology, or in a related field, and have a strong record of publications. Prevalence will be given to candidates with experience in gene-editing in cells and mice, live-cell imaging, super-resolution imaging, or intravital imaging. People with disease models in mice, such as myocardial ischemia-reperfusion injury, are encouraged to apply. Interested candidates should send their CV, representative publications, and names of three references to Dr. Zhichao Fan (zfan@uchc.edu).