杜克大学抗生素抗药性，二型糖尿病方向博士后招聘

Job Description

POSTDOCTORAL FELLOW POSITION Starting JAN 1, 2020 to study RNA-protein and small molecule interactions, drug design and mechanism, Duke University Medical Center

The Agris Lab in the Department of Medicine at Duke University is seeking a full-time Postdoctoral fellow for research in antibiotic resistance, and type 2 diabetes. We are a new lab at Duke focused on a mechanistic understanding of RNAs that control function and impact human disease. The ideal candidate will have research laboratory experience in protein expression and purification as well as some experience with biochemical or biophysical assay development and RNA.

Under the general direction of the Principal Investigator, the Postdoctoral fellow will conduct cloning, expression, and purification of proteins and enzymes, help perform biochemical and structural studies to characterize RNA-protein and small molecule interactions, and contribute to lab maintenance and organization.

MAJOR RESPONSIBILITIES:

• Carry out molecular cloning, expression, and purification to support protein biochemical and structural studies.

• Work closely with Principal Investigator to help develop and carry out biochemical and biophysical assays to monitor enzyme kinetics and enzyme-substrate interactions.

• Contribute to the development and implementation of lab protocols and organizational frameworks to create efficient lab workflows.

• Help with day-to-day lab functions (e.g. instrument maintenance and reagent preparation).

• Maintain a detailed laboratory notebook.

• Present and discuss experimental findings and plans in meetings with the Principal Investigator and research group.

• Help ensure general lab safety standards.

• Perform miscellaneous job-related duties as assigned.

QUALIFICATIONS:

• Bachelor’s and Ph.D. (M.D.) degrees and job-related experience . Degrees in Biochemistry, Chemistry, Molecular Biology, Bioengineering, Medicine or related field preferred.

• Experience in a cell and molecular, biochemical and/or microbiological research laboratory, particularly with RNA.

• Experience with molecular cloning and protein expression and purification methods.

• Knowledge of / experience with standard biochemical assays and/or assay development. Experience with enzymology is a plus.

• Knowledge of / experience with quantitative analysis techniques for protein and small molecule samples. Experience with mass spectrometry is a plus.

• Ability to work both independently and as part of a team.

• Enthusiasm to learn new techniques and take on new roles.

• Excellent communication and organizational skills.

Enthusiastic, imaginative and dedicated RNA scientists wishing to join our research team will find that the RNA community of Duke and UNC is dynamic, diverse and supportive with a history of the longest regional RNA community, seminars, monthly meetings, separate RNA modification group and annual Symposium (https://sites.duke.edu/ncrna2019/).

Applications should consist of a one-page cover letter and a CV including publication record, brief descriptions of previous research accomplishments and techniques, and the names and contact information for three references sent to Dr. Paul F. Agris (Paul.Agris@duke.edu). Informal inquires are welcome. (Foreign applicants are expected to already have a visa to be allowed to enter the US for a research positions on or before Jan 1, 2020.)