美国霍普金斯大学细胞有丝分裂研究博士后职位招聘

Postdoctoral position in the Holland lab at the Johns Hopkins School of Medicine.

· Johns Hopkins University School of Medicine

· Location: Baltimore, MD

· Job Number: 7061460

· Posting Date: Oct 16, 2019

· Application Deadline: Open Until Filled

Job Description

A post-doctoral position is available to start immediately in the laboratory of Dr. Andrew Holland, located at the Johns Hopkins University School of Medicine, Baltimore, Maryland. Johns Hopkins School of Medicine is a world-class institution that is consistently ranked amongst the top three medical research schools in the USA.

The Holland laboratory is studying the molecular mechanisms that control accurate chromosome distribution and the role that mitotic errors play in human health and disease. Our work utilizes a combination of chemical biology, biochemistry, cell biology and genetically engineered mice to study pathways involved in mitosis and their effect on cell and organism physiology. This position is available as early as December 2019.

For more details of our recent publications and research interests please visit our website at www.hollandlab.com.

The successful applicant must have, or be in the process of completing, a PhD. The ideal candidate will have experience in mouse models, cell biology or biochemistry. We also welcome those with backgrounds in engineering, chemistry, and physics who are interested in applying their expertise to biological systems. All candidates must be highly motivated and have a strong record of independent research

Applications should be sent to aholland@jhmi.edu and should include a letter detailing the candidate’s motivation for this position, a full curriculum vitae including a list of publications and the contact details of three individuals who will provide letters of recommendation.

Relevant publications:

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Massive centriole production can occur in the absence of deuterosomes in multiciliated cells.

Mercey, O.#, Levine, M.S.#, LoMastro, G. M., Rostaing, P., Brotslaw, E., Gomez, V., Kumar, A., Spassky, N., Mitchell, B.J., Meunier, A.*, Holland, A.J.* Nature Cell Biology. In Press.

WBP11 is required for splicing the TUBGCP6 pre-mRNA to promote centriole duplication. Park, E.M., Scott, P.M., Clutario, K., Cassidy, K.B., Zhan, K., Gerber, S.A., Holland, A.J. Journal of Cell Biology. In Press.

PLK4 promotes centriole duplication by phosphorylating STIL to link the procentriole to the microtubule wall.

Moyer, T.C. and Holland, A.J. eLIFE 8: e46054. (2019).

Once and only once: mechanisms of centriole duplication and their deregulation in disease.

Nigg, E.A., Holland, A.J. Nature Reviews Molecular Cell Biology 19(5): 297-312. (2018).

Centrosome amplification is sufficient to promote spontaneous tumorigenesis in mammals.

Levine, M.S., Bakker, B., Boeckx, B., Moyett, J., Lu, J., Vitre, B., Spierings, D.C., Lansdorp, P.M., Cleveland, D.W., Lambrechts, D., Foijer, F. and Holland, A.J. Developmental Cell 40(3): 313-22. (2017).

A USP28-53BP1-p53-p21 signaling axis arrests growth following centrosome loss or prolonged mitosis.

Lambrus, B.G., Daggubati, V., Uetake, Y., Scott, P.M., Clutario, K.M., Sluder, G., Holland, A.J. Journal of Cell Biology 214:143-153. (2016).