美国特拉华大学化学与生物化学博士后职位招聘

Post Doctoral Fellow, Chemistry and Biochemistry

· University of Delaware

· Location: Newark, DE

· Job Number: 7062789

· Posting Date: Dec 16, 2019

· Application Deadline: Open Until Filled

Job Description

The Rozovsky research group is looking for a Postdoctoral Fellow to join our investigation of the contribution of membrane enzymes to the function of complex protein machineries. The new team member will join our efforts toward understanding protein quality control involving the ER-associated protein degradation (ERAD) pathway. The ERAD complex itself is responsible for handing misfolded protein and protein assemblies to the proteasome for degradation, a process that, if impaired, is strongly linked to neurodegenerative and protein misfolding diseases.

This NIH-funded project focuses on two integral membrane selenoproteins (SELENOS and SELENOK) that contribute to the ERAD pathway. Selenoproteins are a specialized group of enzymes that contain the reactive amino acid selenocysteine and they are primarily involved in oxidative health and redox biology. SELENOS is an adaptor responsible for recruitment of the protein p97 which delivers the energy for unfolding and pulling proteins to the ERAD complex. However, the timing and specific location of p97 employment is tightly controlled because this protein takes part in several other cellular processes. It appears that this control of p97 by SELENOS is particularly important when the ER is under oxidative stress. In contrast, SELENOK’s precise function is still unknown, but maybe related to palmytoilation of ERAD components and thus this selenoprotein is potentially involved in the management of location and lifetime of complex members.

To study the contributions of SELENOS and SELENOK to the ERAD complex, biochemical assays, cellular studies and structural characterizations will be carried out. Thus, the successful candidate must have attained a PhD in Biochemistry, Structural Biology, Molecular Biology, Chemical Biology, Biophysics or any related field.

This is a temporary position, with an initial appointment of one year. Continuation of the position is contingent upon funding and satisfactory research progress.

Location: The University of Delaware is a large research university with more than 22,000 students. It is located in the very affordable, family-friendly and safe town of Newark, DE. The town is within half an hour of the Philadelphia International Airport and a short drive to downtown Philadelphia, Baltimore and Washington D.C.

The Department of Chemistry & Biochemistry is known for its collegiality and strong interdisciplinary training and research. Our new team member will have the opportunity to interact with different faculty within the Department as well as research groups across campus.