美国克利夫兰诊所癌症免疫学博士后职位招聘

Postdoctoral Research Fellow in Cancer Immunology

· Cleveland Clinic

· Location: Cleveland, OH

· Job Number: 7062936

· Posting Date: Jan 7, 2020

· Application Deadline: Open Until Filled

Job Description

Postdoctoral fellow positions are available in Dr. Li Lily Wang’s laboratory, in the Department of Translational Hematology Oncology Research (THOR), https://www.lerner.ccf.org/thor/wang/ in the Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH. The Wang laboratory is engaging in cross-disciplinary studies by collaborating with basic and clinical researchers from LRI /CCF and the Case Comprehensive Cancer Center, affiliated with Case Western Reserve University.

Immune-checkpoint blockade (ICB) therapies have revolutionized the field of Cancer Immunotherapy. However, the low response rate in a majority of patients indicates the urgent need to identify and target additional checkpoint regulators. The Wang laboratory is among the first group to demonstrate that the immune-checkpoint protein “VdomainImmunoglobulinSuppressor ofTcellActivation” (VISTA) is a promising target for cancer immunotherapy (1 – 6). Our studies show that VISTA regulates the effector functions of cytotoxic T cells, myeloid-derived suppressor cells (MDSC), and myeloid inflammatory DCs. Current projects are focusing on elucidating the molecular signaling mechanisms of VISTA and design innovative approaches to target this checkpoint protein for cancer therapy.

We seek talented and committed candidates with a recent Ph.D. in Biochemistry, Cell Biology, Immunology, or other relevant branches of biological sciences to join our team and make significant contributions to the field of Cancer Immunotherapy. Interested candidates should submit CV, a statement of research interests in a cover letter, and three references to Dr. Li Lily Wang, wangl9@ccf.org.