西雅图儿童研究所2020年博士后招聘（结核病药物研发）

TB remains a serious global health problem and there is an urgent need for new therapeutic agents and an increased understanding of antibiotic resistance. The Parish Lab is looking for a post-doctoral scientist to work on a tuberculosis drug discovery project. The successful candidate will work in a multi-disciplinary research environment interacting with chemists and biologists. The main research project is to determine the mode of action of new compounds classes under development as TB drugs. Work will also involve target identification, confirmation, and validation, as well as determining mechanisms of drug resistance.

Description of Responsibilities:

Conduct a research and development project

Design and implement research plans

Work under Biosafety Level 3 conditions with Mycobacterium tuberculosis

Troubleshoot and solve experimental and technical problems

To prepare and present papers, reports, and presentations of current research work

Write manuscripts and assist with grant preparation

Write standard protocols and validation data packages

Oversee quality control and data integrity

May supervise one or more research assistants

Specific duties include:

Conduct research into mechanism of kill of new inhibitors

Use multiple approaches to identify and validate drug targets

Research into mode of resistance of new inhibitors

Run a wide range of microbiological and cellular assays

Culture and genetic manipulation of mycobacteria

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