瑞典卡罗琳研究院2020年招收博士后

Do you want to contribute to top quality medical research?

A postdoc position on the role of 3D genome organization in prostate cancer is immediately available in the Bienko-Crosetto lab for Quantitative Genome Biology at the Science for Life Laboratory (SciLifeLab) in Stockholm.

As a postdoc, you will develop and lead an exciting project aimed at exploring how the higher-order genome architecture changes moving from normal tissue to in situ lesions to invasive tumor areas, in patient-derived prostate cancer samples.

You will work in a dynamic research environment focused on basic genome biology, molecular methods development and oncogenomics (https://bienkocrosettolabs.org/). At SciLifeLab and Karolinska Institutet, you will have the opportunity to network with scientists and clinicians from many diverse fields and backgrounds, fostering your creativity and shaping your project from a non-conventional perspective.

Your mission

You will use Hi-C and other well-established genome-wide methods (ATAC-seq, RNA-seq) and apply them to multiple regions of fresh-frozen prostate cancer samples that are already available in our lab.

In parallel, you will apply spatial transcriptomics and AI-based image analysis techniques to differentiate between normal prostate tissue, in situ carcinoma regions and invasive tumor areas, and then examine how the 3D genome and genome-wide accessibility/transcriptome (co-)vary across these regions.

Your ultimate goal will be to develop an integrated model of how the (epi)genome is rewired during the process of tumorigenesis in the prostate and contribute to the identification of novel disease biomarkers and potential therapeutic targets.

Your profile

Are you experienced in Hi-C or other epigenomic techniques and are currently working in the field of genome organization? Are you interested in bringing your knowledge on genome organization to the cancer biology field? Do you want to work in a highly inter-disciplinary environment, working together with clinicians, biologists and data analysts to tackle complex biomedical problems? Then you are the right person!

You are not expected to know how to code or how to analyze complex datasets, but you are definitely expected to work in synergy with experts in bioinformatics and data science on a daily basis.

Qualified to be employed as a postdoctor is one who has obtained a doctorate or has equivalent scientific competence. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) date of employment. This must be substantiated by the applicant’s main supervisor, director or equivalent.

What do we offer?

A creative and inspiring environment full of expertise and curiosity. Karolinska Institutet is one of the world’s leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. Karolinska Institutet is a state university, which entitles to several benefits such as extended holiday and generous occupational pension. Employees also have access to our modern gym for free and receive reimbursements for medical care.

Location: SciLifeLab, Stockholm/Solna

Application

An employment application must contain the following documents in English:

· A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work

· A complete list of publications

· A summary of current work (no more than one page)

· Verifications for crediting of illness, military service, work for labour unions or student organisations, parental leave or similar circumstances

· Verification from the thesis defence committee or the equivalent (only if the thesis defence is scheduled within three months after the application deadline)

Welcome to apply at the latest 30th of June

The application is to be submitted through the Varbi recruitment system.