美国纽约大学格罗斯曼医学院Perlmutter癌症中心飞利浦实验室2020年博士后研究员招聘

Two postdoctoral positions are open in the Laboratory of Mark Philips in the Perlmutter Cancer Center at NYU Grossman School of Medicine in New York City. The Philips Lab focuses on the interplay between subcellular trafficking and signaling by small GTPases, particularly RAS oncogene products. We study/investigate how signal outputs depend on specific subcellular compartments and how one might interfere with protein trafficking to design novel therapeutics. We apply a wide range of tools from enzyme kinetics to live cell imaging in organisms from Drosophila to mice. Recent work includes the discovery that hexokinase 1 is directly regulated by KRAS4A (Nature, 2019) and the development of screens for KRAS4B membrane association that identified a nuclear factor that regulates prenyltransferase gene expression (in revision, PNAS). Open projects include, but are not limited to, the details of regulation of hexokinase on the outer mitochondrial membrane by KRAS4A, the mechanism of control of KRAS alternative splicing and the expression of KRAS splice variants at the single cell level in tumors, the regulation of KRAS4A palmitoylation, control of KRAS4B membrane association by a protein kinase, regulation of farnesyltransferase expression by a nuclear scaffold protein, and the role of carboxyl methylation on NRAS trafficking and signaling in melanoma. Funding sources include a National Cancer Institute Distinguished Investigator Award. For more information see https://www.philipslab.org/

Qualifications: PhDs with experience in molecular cell biology and/or basic cancer biology are encouraged to apply. Familiarity with basic bioinformatic analysis is desired. We seek candidates who are independent and creative thinkers and who value a highly collaborative environment. Qualified candidates will have a track record of publication in peer-reviewed journals and should be competitive for research fellowships.

Application materials: Send a cover letter, CV and list of at least 3 references to philim01@nyulangone.org.