美国哥伦比亚大学2020年招聘博士后职位（功能基因组学（衰老相关））

ASSOCIATE RESEARCH SCIENTIST: the genetic components of aging and aging-related diseases using a functional genomics approach

Columbia University

Posting DetailsJob Requisition Number 00001888

Field(s) of Specialization Molecular biology, bioinformatics Position Title Associate Research Scientist Department OBG OBGYN Division OBGYN Location Summary Description

Suh lab's long-term research goal is to investigate the genetic components of aging and aging-related diseases using a functional genomics approach. By integrating large scale human genetic and epigenomic datasets, Suh lab focuses on the identification of gene sequence variations in candidate genes and the assessment of their potential functional impacts on aging-related phenotypes. Further investigation needs to be done in specific functional tests to any genetic variations found to be significantly associated with one or more defined aging phenotypes by using in silico modeling, as well as in vitro and in vivo studies.

Position summary: The associate research scientist will focus on the functional analysis of the genomic variations in genes involved in genome stability and proteostasis pathways that contribute to aging and longevity in humans. Responsibilities will include analyzing bioinformatics resources, performing cell-based assays, and molecular assays.

Responsibilities: 1. Perform analysis of bioinformatics datasets, including aging-related transcriptome and proteomic datasets, human genetic and functional genomic datasets related to human aging and longevity. 2. Identify gene sequence variations in genes of genome stability and proteostasis pathway related to human aging and longevity. 3. Establish knock-in hESCs lines and their derivations to functional study of gene sequence variations in various human cell types. 4. Perform functional studies of candidate gene sequence variations in cell or mouse models. 5. Establish proteomic methods to study the functions of candidate proteins.

Minimum Degree Required

A Ph.D. degree with 2-4 years in related academic research experience is required such as molecular biology, cellular biology or other related field.

Minimum Qualifications

- Strong background in proteomic or cellular biology is required, including prior experience in proteomic techniques, molecular and cell biology techniques, such as Mass Spectrometry, CRISPR/cas9-based gene-editing, hESC differentiation, shRNA-based gene silencing, cell-based assays, Co-IP, Western Blots, etc.

- Ability to work independently, design experiments, follow and adopt protocols, conduct, interpret, and optimize experimental studies.

- Excellent verbal and written communication skills are required.

- Excellent team working skills and adaptability are required.

Preferred Qualifications

- A basic understanding of bioinformatics is preferred. Experience in analyzing large-scale bioinformatics datasets, including transcriptome datasets, human genetic datasets, and functional genomic datasets is a plus.

Additional Information RAPS posting date 09/18/2020 Search Closing Date Special Instructions to the Applicant Proposed Start Date EEO Statement

Columbia University is an Equal Opportunity Employer / Disability / Veteran

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