美国约翰霍普金斯大学2020年招聘博士后职位（表观遗传学方向）

Postdoctoral Fellowat Johns Hopkins University

Location: Baltimore, MD

Job Number: 7072665

Posting Date: Nov 30, 2020

Application Deadline: Open Until Filled

Job Description

A postdoctoral fellow position is available in the Dr. Zhibin Wang’s Laboratory of Environmental Epigenomes at Johns Hopkins University Bloomberg School of Public Health. Our long-term goal is to answer a series of questions that are classic in the fields of epigenetics and environmental health sciences. The three questions below are innately linked and answering one of them helps to address the remaining two. Specifically, we ask (1) What kind of epigenetic codes/patterns exists in the human/mouse genome (Cell 2007 PMID:17512414; Cell 2008 PMID: 18329373; Nature Genet. 2008 PMC2769248; Immunity 2009 PMC2709841; CurrOpin Genet Dev. 2009 PMC2699568; BMC Genomics. 2009 PMC2667539; Nature 2011 PMC3539771; Genes Dev. 2011 PMC3070931; Genome Biol. 2015 PMC4474455; Cell Discov. 2017 PMC5787696); (2) How these patterns are established by corresponding enzymes for normal development and/or differentiation (Cell 2009 PMC2750862; Science 2010 PMC3008398; Nature 2010 PMC3072215; Sci Rept. 2015 PMC4671053; Nucleic Acids Res. 2016 PMC4856969; Mol Cell 2016 PMC4975651), and (3) How this establishment goes awry upon environmental exposure, thereby contributing to the etiology of human diseases (e.g., obesity/T2D, Parkinson’s disease, and cancer) (Curr Environ Health Rep. 2014; ProgBiophysMol Bio., 2015 PMC4784256; Nature Biotech. 2018 PMC5991835; ExpNeurol 2018 PMID:30076829; ToxicolApplPharmacol. 2018 PMID: 30130555; Food ChemToxicol. 2018 PMID: 30171970; Front Genet. 2018 PMC6334214; bioRxiv 2019 doi: https://doi.org/10.1101/808246; Environ. Int. 2020, PMID: 32059142; Environ. Toxicol. Pharmacol.2020 PMID: 32380377; Epigenetics Chromatin. 2020, PMC7076959; Front Genet. 2020 PMID: 32774342).

To our goals, the Wang laboratory uses multidisciplinary approaches, including house-developed bioinformatic algorithms (ACE-mapping, NORED, and MethylMosaic) and epigenomic techniques (ChIP-seq (ZW as original developer), ATAC-seq, WGBS-seq, as well as RNA-seq). With these techniques, fellows have golden opportunities to be trained in a multidisciplinary fashion. We expect highly self-motivated young scientist, with relevant Ph.D degrees and experiences, to join our exciting research programs for epigenomic insights of environmental diseases.

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