美国芝加哥大学2021年招聘博士后职位（卵巢癌生物学）

The Lengyel Laboratory (https://obgyn.uchicago.edu/research/lengyel-ovarian-cancer-laboratory) is seeking a highly motivated postdoc to join our laboratory’s efforts to understand human ovarian cancer biology. Our laboratory studies the role of the microenvironment in ovarian cancer development and progression; using knowledge gained to develop novel treatments for metastatic ovarian cancer. The postdoc will have the opportunity to work in a multi-disciplinary environment in close collaboration with physicians, device fabrication engineers, statisticians, and molecular and systems biologists at the University of Chicago.

The position will focus on understanding the biology of ovarian cancer stem cells using state-of-the-art mass cytometry, spectral flow cytometry, and high throughput screening. We are interested in chemo-resistant subpopulations of ovarian cancer cells, including stem cells, and aim to elucidate the role these subpopulations have on the tumor microenvironment and chemoresistance. A high-throughput screening program has been employed to identify and confirm a combination of FDA-approved drugs that effectively target these subpopulations of ovarian cancer cells, and to identify the pathways critical for their survival.

Job Requirements:

· PhD, MD, or equivalent doctoral degree in systems biology, molecular biology, cancer biology, biochemistry, chemical or biomedical engineering

· Record of scientific achievement through publications and presentations

· Strong track record in design and execution of experiments and a passion for translational science

· Excellent written and spoken communication skills in English

· Ability to conduct research independently; interest in mechanistic research

· Superb problem solving skills

· Exceptional interpersonal skills

· Impeccable wet lab skills

· Experience with flow cytometry, optical microscopy, immunohistochemistry, immunofluorescence, molecular biology, and sequencing are strongly desired

· Familiarity with next-generation sequencing data and bioinformatics will be advantageous

Please email Ernst Lengyel at lengyeloffice@bsd.uchicago.edu with a brief statement regarding research interests, CV, and a list of two references with their email addresses.

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