德国海德堡大学医院人类遗传学研究所2021年招聘博士后

Postdoctoral Position With Combined Wet And Dry Lab Work At The Institute Of Human Genetics (M/F/D)

Heidelberg University Hospital

Description

Postdoctoral position with combined wet and dry lab work at the Institute ofHuman Genetics (m/f/d)

JobID: P0025V441

at the earliest possible date searched for, AG Laugsch at the Institute of Human Genetics.

We are looking for an enthusiastic postdoc to join our research group at the Institute of Human Genetics of the University of Heidelberg. The position is limited to 3 years, with the option of further extension. The salary is based on TV-L salary groups.

Our laboratory explores the relationship between the head (craniofacial structures) and brain development in health and disease. We focus on developmental genes specifically and dynamically regulated, e.g., by enhancers. That regulation ensures the establishment of precise gene expression patterns during development, which might have pathological consequences when being disrupted.

Composed of international and multi-disciplinary scientists, our group creates a unique and inspiring environment and supports individual career development. For more information visit:

https: // www. klinikum.uni-heidelberg.de/humangenetik/forschung/abt- humangenetik/ag-laugsch.

(Magdalena Laugsch et al., Cell Stem Cell. 2019 May 2; Modelling the pathological longe-range regulatory effects of human structural variation with patient-specific hiPSC.;24(5):736-752)

Tasks and responsibilities

Creating and analyzing next-generation sequencing data, the successfull applicant will investigate the impact of cohesin on neural crest cells (hNCC) development and their contribution to Cornelia de Lange Syndrome (CdLS). This rare but severe genetic disorder is caused by mutations in the cohesin complex or and its auxiliary factors and characterized by craniofacial and limbs malformations, heart defects, and cognitive deficits. Cohesin regulates the three-dimensional (3D) structure of chromatin and impacts the regulation of gene transcription. A large set of craniofacial abnormalities observed in CdLS patients most likely arises during the embryonic development of the hNCC. Hence, the postdoc will investigate the underlying molecular defects in hNCC derived from human induced pluripotent stem cells (hiPSC). Combining genetic, epigenetic, and bioinformatic tools (hiPSC culture, CRISPR/Cas9 targeting, hNCC differentiation, RNA- and scRNA-seq, Hi-ChIP-seq, ATAC-seq, and analysis using advanced bioinformatics), the scientist will identify the 3D structure of chromatin and regulatory networks controlled by cohesin.

Your Profile

Ph.D. in bioscience or equivalent degree with a substantial experience in stem cell biology and bioinformatics.

Basic experience in hiPSC culture , CRISPR/Cas9 targeting and their differentiation.

Ability to analyze your own data and significant proficiency as well as strong interest in Python, R, shell scripting and working with NGS data.

Curiosity-driven researcher, passionate about science, who can work both independently and as part of our team.

Strong written and verbal communication skills in English.

We offer

An exciting, DFG-funded translational research project

A stimulating work environment within a highly motivated, international team of researchers, scientific collaborations both within the Institute and across the life science community

Target-oriented individual education and training opportunities

Targeted training on the job

Ticket for public transport

Possibility of childcare (nursery and kindergarten) as well as subsidy for holiday care for school children

Active health promotion

Company pension scheme

Access to the university library and other university facilities (e.g. university sports)

Contact & Application

The application must include your motivation, a brief statement of your scientific interests, contact details from three references, curriculum vitae, separated publication list, and relevant certificates.

Please forward your complete application ( in a single pdf document - Filename: P0025V441First NameSecond Name – No other format will be accepted ) until 30.09.2021 by e-mail.

Universitätsklinikum Heidelberg InstitutfürHumangenetik Dr. rer. nat. Magdalena Laugsch, Group Leader ImNeuenheimer Feld 366 69120 Heidelberg Tel.: +49 6221 56-39128 magdalena.laugsch@uni-heidelberg.de

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