丹麦哥本哈根大学2021年招聘博士后职位（蛋白质信号）

Postdoc Position in Protein Signaling At Novo Nordisk Foundation Center for Protein Research

Copenhagen University

Description

We are looking for an excellent and highly motivated postdoctoral researcher to join the Nilsson lab. The position is fully funded for 1 year starting early 2022. The exact starting date is flexible and can be negotiated.

Job description The Nilsson lab focuses on understanding how protein phosphatases achieve specificity and how this regulates signalling in cells. A key focus is on short linear motifs (SLiMs) that mediate specific interactions between substrates and protein phosphatases. We are looking for a post doc interested in exploring SLiM mediated interactions and how they control phosphatase specificity. The position will entail cell based assays as well as enzymatic and biochemical approaches. As a postdoctoral member you will be part of a vibrant international and interdisciplinary research environment with a collaborative spirit.

Our research Protein phosphatases have been viewed as unspecific enzymes that merely act to counteract the specific kinases, but research in recent years has revealed that protein phosphatases are in fact tightly controlled and act precisely on specific substrates. The group has uncovered general principles of substrate selection for the PP2A-B56 phosphatase (Hertz et al, Mol Cell 2016) and PP4 (Ueki et al, Mol Cell 2019). This work has shown that SLiMs are key determinants of specificity for phosphatases and that these interactions are regulated by phosphorylation of the SLiMs. A careful characterization of SLiMs allows for a system wide understanding of pathways regulated by protein phosphatases. In addition to providing a full picture of pathways regulated by phosphatases SLiM mediated interactions are also ideal targets for small molecule inhibitors and can pave the way for the first inhibitors able to target a specific phosphatase.

Qualifications of the candidate The candidate should have a deep knowledge and practical experience with cell- based assays. Prior experience with protein phosphatases is an advantage. We are looking for an excellent candidate with outstanding academic track- records, who have a strong desire to explore protein phosphatases. It is anticipated that the candidate can work effectively in a team and also independently carry out research. Candidates for the postdoctoral positions must hold a PhD degree (or equivalent) and are expected to have demonstrated outstanding achievements in their field of research.

Place of employment The employment is at CPR (www. cpr.ku.dk), a Novo Nordisk Foundation center of excellence established in 2007 and embedded in the Faculty of Health and Medical Sciences, University of Copenhagen, to promote basic and applied research on human proteins of medical relevance. Copenhagen is a beautiful, accessible and vibrant city, consistently ranked as one of the most desirable places to live in the world. The Center comprises modern laboratories, supercomputer resources and state-of-the-art technological platforms including advanced protein imaging. CPR is an interdisciplinary international environment with English as the main language. We are located in central Copenhagen, a city with one of the highest qualities of life in the world and a vibrant and highly interactive research environment. The University of Copenhagen has a strong focus on balancing professional life with a family- friendly working environment (https: // www. ism.ku.dk/faq). Furthermore, Denmark as a country is constantly at the absolute top of the World Happiness Report rankings year after year (https: // worldhappiness.report/).

Terms of employment The employment as postdoc is a full time and fixed-term position for 1 year. Starting date is early 2022, or after agreement.

Salary, pension and terms of employment will be in accordance with the agreement between the Danish Ministry of Finance and AC (Danish Confederation of Professional Associations). Currently, the monthly salary starts at 35,915 DKK/ approx. 4,829 Euro (October 2021-level). Depending on qualifications, a supplement may be negotiated. The employer will pay an additional 17.1 % to your pension fund.

Non-Danish and Danish applicants may be eligible for tax reductions, if they hold a PhD degree and have not lived in Denmark for the last 10 years.

The position is covered by the “Memorandum on Job Structure for Academic Staff at the Universities” of December 2019.

Questions For further information please contact Professor Jakob Nilsson, Jakob.nilsson@cpr.ku.dk

Foreign applicants may find this link useful: www. ism.ku.dk (International Staff Mobility).

Application procedure Your online application must be submitted in English by clicking ‘Apply now' below. Furthermore, your application must include the following documents/attachments – all in PDF format:

Motivated letter of application.

CV incl. education, work/research experience, language skills and other skills relevant for the position.

A certified/signed copy of a) PhD certificate and b) Master of Science certificate. If the PhD is not completed, a written statement from the supervisor will do.

List of publications.

Application deadline: 15 November 2021, 23.59pm CET

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