美国堪萨斯州立大学2021年招聘博士后（诊断学/病理生物学）

Fellow (Post Doc) (Diagnostic Medicine / Pathobiology)

Kansas State University

Description

Fellow (Post Doc) (Diagnostic Medicine / Pathobiology)

Apply now Department: 3670080040 Diagnostic MedicnePathobiolog Job no: 511757 Employment type: Staff Full Time (Unclassified - Term) Location: Manhattan, Kansas Categories: Research / Scientific / Grants, Veterinary Medicine Pay Grade: 001

About this Role:

The Department of Diagnostic Medicine/Pathobiology within the College of Veterinary Medicine is seeking applicants for a Fellow (Post Doc.) This postdoctoral fellow will be responsible for conducting research in identification of protective Japanese Encephalitis Virus (JEV) antigens, formulation of prototype vaccines, and conducting efficacy studies in pigs. Additional area of research will involve mapping B cell epitopes for potential use in development of diagnostic test that would be a good fit for differentiation of infected from vaccinated animals. Some efforts will also be directed at the optimization of EliSpot readouts for quantification of JEV- specific granzyme B-positive T cells by intracellular staining. The research project will utilize multiple live vector platforms, and studies will be conducted in commercial swine at BSL2/3 levels. Previous hands-on experience in molecular and cell biology, immunology, vaccinology, and animal husbandry is required.

Why Join Us:

Kansas State University offers a comprehensive benefits package that includes health insurance, life insurance, retirement plans, paid time off – vacation, sick, and holidays. To see what benefits are available, please visit: https: // www. k-state.edu/hcs/benefits

We Support Diversity and Inclusion:

Kansas State University embraces diversity and promotes inclusion. The University actively seeks individuals who foster a collegial environment and cooperative interactions with coworkers, students, and others. The University is dedicated to promoting the Principles of Community.

Duties / Responsibilities:

Determine cellular immune responses required for protection of pigs against Japanese Encephalitis Virus (JEV).

Utilize the knowledge, and contemporary technology and approaches to rationally identify JEV antigens that induce the protective immunity.

Design, generate, quality control validate recombinant live-vectored prototype vaccines. Multiple live vectors will be used to generate the vaccine candidates.

Conduct prototype vaccine safety, tolerability, and immunogenicity studies in pigs. The in vivo studies will be conducted combinations in dose escalation/dose limiting studies.

Evaluate protective efficacy of lead prototype vaccine in pigs.

Participate in planning experiments.

Data analysis and interpretation.

Generate technical reports and manuscripts.

Participate in research proposal development.

Submit intramural and extramural grant proposals.

Train new students and provide oversight of daily programmatic activities.

Ensure compliance with IBC Federal and University regulations that govern research at BSL-2/BSL-3 levels and IACUC.

Required Minimum Qualifications:

Ph.D. training in Molecular Biology/Immunology/Vaccinology

Hands-on experience generating live-vectored subunit vaccines, generation and affinity purification of recombinant proteins using mammalian cells/insect cells/yeast, conducting safety/immunogenicity and experimental vaccine efficacy studies in pigs, hands-on experience conducting cytotoxic T lymphocyte killing assays using chromium-release assay or other assays, conducting EliSpot assays using swine lymphocytes

Preferred Qualifications:

Experience with analysis and interpretation of vaccine response data from swine

Proposal development

Hands-on skills in generating and maintaining primary swine T cells and fibroblasts

Skill in bioinformatics and FACS

Excellent oral and written communication skills

Other Requirements:

All K-State employees must be fully vaccinated against COVID-19 (unless granted an exemption by the university) by December 8, 2021 or their first day of employment, whichever is later, pursuant to the federal executive order for federal contractors. To learn more about this requirement and potential exemptions, please visit K-State's COVID-19website.

Special Instructions to Applicants:

Please submit cover letter, resume, and contact information for three professional references

Screening of Applications Begins:

Screening of applications begins immediately and will continue until the position is filled.

Salary Range / Pay Rate:$ 47,476 - $ 55,000 annual salary

Equal Employment Opportunity:

Kansas State University is an Equal Opportunity Employer. All applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender, gender identity, age, national origin, disability or status as a protected veteran.

Background Screening Statement:

In connection with your application for employment, Kansas State University will procure a Background Screen on you as part of the process of considering your candidacy as an employee.

Advertised: Nov 07, 2021 Central Standard Time Applications close: Open until filled

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