瑞士苏黎世联邦理工学院2022年招聘博士后（基于磷酸蛋白质组学的细胞信号研究）

Postdoc Position – Phosphoproteomics Based Studies Of Cell Signalling

ETH Zurich

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Postdoc position – Phosphoproteomics based studies of cell signalling

100%, Zurich, fixed-term

The Institute of Molecular Systems Biology at ETH Zurich is inviting applications for a Postdoctoral Fellow in the laboratory of Prof. Pedro Beltrao.

Project background

The group of Prof. Beltrao has a long standing interest in the study of protein post-translational modifications (PTMs) and their regulatory systems with a specific focus on protein phosphorylation and kinase regulation. While regulation by phosphorylation has been studied for decades, only recently we do have the technologies to detect and measure changes in phosphorylation sites at the whole cell level. However, we lack an understanding of how PTMs and their regulatory systems operate beyond some highly studied examples. The majority of PTM positions and most of the enzyme regulators remain to be studied, indicating that our knowledge of these systems remains highly incomplete and biased. Our group has been developing methods to study, in large scale, the evolution of phospho-regulation (Studer et al. Science 2016; Bradley et al. PLoS Bio 2019), the functional relevance of phosphorylation sites (Viéitez et al. Nat Biotech 2021; Ochoa et al. Nat Biotech 2020) and the reconstruction of kinase signalling circuits (Invergo et al. Cell Systems 2020).

Job description

Applicants with a background in mass spectrometry are invited to develop (phospho)proteomics based research projects that will contribute to a better understanding of eukaryotic protein phospho-regulation at the level of the whole cell. Areas of interest in the lab include: the function and evolution of phosphorylation; the dynamics and regulatory principles of kinase circuits; the context dependent changes in kinase circuits; and the dysregulation phospho-regulation in disease.

Your profile

Doctoral degree in cell signalling using mass spectrometry based proteomics

Proactive personality, excellent communication skills and capacity to work with a diverse group of people

Strong background in mass spectrometry is required

Working experience with high-throughput approaches and large number of samples is preferred

Experience with phosphoproteomics and cell signalling is preferred

Experience with S. cerevisiae or mammalian systems is preferred

Further, any expertise in programming is of advantage

We offer

You will have access to a dedicated MS instrument and be part of a team of scientists with diverse expertise, including yeast genetics and cutting-edge development of computational approaches in the area of cell signalling. The Institute of Molecular Systems Biology is at the forefront of MS technology development and systematic approaches to study biological systems. The broader world leading research at ETH has major strengths that complement the research of the institute. You will have the opportunity and flexibility to develop your career plan in the direction of interest and have support for training.

ETH Zurich

ETH Zurich is one of the world's leading universities specialising in science and technology. We are renowned for our excellent education, cutting-edge fundamental research and direct transfer of new knowledge into society. Over 30,000 people from more than 120 countries find our university to be a place that promotes independent thinking and an environment that inspires excellence. Located in the heart of Europe, yet forging connections all over the world, we work together to develop solutions for the global challenges of today and tomorrow.

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Interested?

We look forward to receiving your online application by March 20th 2022 with the following documents:

Cover letter describing your background and motivation

CV and publication list

Contact information of 2 – 3 potential referees

Evaluation of applications will start on 21st March 2022, but later applications will also be considered until the position is filled and the online application window has been closed.

Please note that we exclusively accept applications submitted through our online application portal. Applications via email or postal services will not be considered. For further information about the position and the group please contact Prof. Pedro Beltrao by e-mail: beltrao@imsb.biol.ethz.ch (no applications) or visit our website www. imsb.ethz.ch.

In line with our values, ETH Zurich encourages an inclusive culture. We promote equality of opportunity, value diversity and nurture a working and learning environment in which the rights and dignity of all our staff and students are respected. Visit ourEqual Opportunities and Diversity website to find out how we ensure a fair and open environment that allows everyone to grow and flourish.

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