荷兰莱顿大学2022年招聘博士后职位（iPSC技术发现Nrf2抗氧化反应调节的靶向治疗）

Postdoc – iPSC technology to discover targeted therapy for Nrf2 antioxidant response modulation.Leiden University

Description

Key responsibilities Cellular stress response pathways are activated in various diseases, including acute ischemia reperfusion injury of liver and kidney, or during neurodegeneration in Parkinson's and Alzheimer's disease. These stress response pathways involve oxidative stress, unfolded protein response, DNA damage and inflammatory signaling. Typically, these responses drive repair processes in cells and prevent ultimate cell death. Likewise, pharmacological modulation of these stress responses can enhance cellular adaptation and repair programs in various disease settings. Here we aim to establish a platform for drug discovery for therapeutic modulation of stress response pathways, with a focus on the Nrf2 antioxidant stress response. The postdoc will establish a panel of iPSC fluorescent reporter systems for critical Nrf2 target genes. These reporters lines will be differentiated into liver, kidney and neuronal cells and applied to a imaging-based screening workflow to uncover novel chemical entities that can protect cells against sustained oxidative stress.

Selection Criteria • PhD in Biomedical Sciences, Biology, Toxicology, (Bio)-pharmaceutical Sciences, • enthusiastic and ambitious • independent thinker • expertise in (human) stem cell culture, molecular and cell biology, microscopy, cell signaling • excellent writing skills • interest in bioinformatics • team player

Our faculty & Institute The Faculty of Science teaches more than 5,000 students in the context of 8 bachelor's and 15 master's programmes. Working at the Faculty of Science means being part of an exciting, dynamic scientific environment which sets high standards for its students, staff, and support staff alike. The faculty is known for its friendly and team-spirited atmosphere, which promotes mutual exchange of knowledge. For more information, see https: // www. science.leidenuniv.nl.

Terms and conditions We offer a full-time, 1 year term position, with the possibility of renewal for an additional 2 years based on performance. Salary range from