丹麦哥本哈根大学2022年招聘博士后（生物信息学/表观遗传学/转录学）

Postdoc in bioinformatics/epigenetics/transcription at Novo Nordisk Foundation Center for Protein Research

A highly attractive postdoctoral position is available in the Choudhary group at the Novo Nordisk Foundation Center for Protein Research (CPR – www.cpr.ku.dk), University of Copenhagen. Expected starting date on 15 September 2022 or after agreement.

About the groups

The Choudhary lab is technically and internationally diverse and embedded in an excellent environment that supports high-quality research and encourages interdisciplinary collaboration. The Choudhary lab conducts experimental and computational research using interdisciplinary, state-of-the-art technologies, including quantitative proteomics, next-generation nucleic acid sequencing, advanced microscopy, CRISPR-based genome editing, and bioinformatics. The lab uses diverse cell models, including embryonic stem cells and their differentiated derivatives.

The Choudhary lab shares the laboratory space with the group of Prof. Matthias Mann and works closely with his group. The group extensively collaborate with top-level international researchers, routinely publish in top-ranked journals, and have an outstanding track-record in training the next generation of researchers. The major publications from the groups include Narita et al., Mol Cell. 2021, Narita et al. Nat Rev Mol Cell Biol 2019; Weinert and Narita et al., Cell 2018; Gupta et al., Cell 2018; Scholz et al., Nat Biotech 2015; Weinert et al., Mol Cell 2013; Povlsen and Beli et al., Nat Cell Biol 2012; and Beli et al. Mol Cell 2012.

We are now looking for enthusiastic candidates with a PhD and/or MD (i.e. level of education corresponding to the Danish PhD degree).

Project description

Through quantitative proteomics, our group revealed the proteome-wide targets of the acetyltransferases CBP/p300, and quantified in-vivo turnover rates for thousands of sites (Weinert and Narita et al., Cell 2018). Recently, we provided a functional link between CBP/p300-catalyzed acetylation and rapid gene regulation and identified the Pol2 “recruit-and-release” as a novel mechanism of enhancer-mediated dynamic transcription control (Narita et al., Mol Cell. 2021). The current project builds on our recent work and aims to understand the epigenetic basis of gene transcription regulation, with a focus to understand how distal-acting enhancers control gene transcription. The project will use experimental data generated from next-generation sequencing. Depending on the candidate´s background, s/he will perform bioinformatic analyses of next-generation sequencing data, including ChIP-seq, RNA-seq, Nascent-seq, ATAC-seq. The candidates with experience in wet-lab and bioinformatics will be able to do both (i.e. work in the wet-lab and perform bioinformatics analyses). If you would like to know more about the project(s), please contact us!

Qualifications

The candidate should have demonstrated excellent scientific productivity, evidenced by high-quality research publications, be able to conduct independent and creative research, and show good interpersonal and communication skills.

◦ The candidate is required to have a PhD degree in natural or medical science.

◦Excellent scientific track-record, including at least one publication in a high-quality, peer-reviewed international journal. Pre-prints can be counted for fulfilling this requirement.

◦Expert knowledge in one or more of the following areas is required: Experience in computer programming languages, such as R, Python

Hands-on experience in analyzing next-generation sequencing dataset, such as ChIP-seq, RNA-seq, ATAC-seq

Strong background in the statistical analysis of large-scale data

Prior experience in CRISPR, epigenetics, and gene transcription regulation.

◦Good communication skills, both oral and written.

◦An analytical aptitude for devising innovative scientific or technical solutions.

◦Demonstrate enthusiasm, motivation, flexibility and confidence.

For further information, please contact Professor Chuna Ram Choudhary, email: chuna.choudhary@cpr.ku.dk.

Foreign applicants may find this link useful: www.ism.ku.dk (International Staff Mobility).

Place of employment and work

The employment is at CPR (www.cpr.ku.dk), University of Copenhagen, located in central Copenhagen. In the past 10 years, CPR has established itself as a top-level research institute in protein signaling and network biology research. The research environment at CPR is ambitious and international, with approx. 30 different nationalities currently represented. The Center comprises modern laboratories, supercomputer resources and state-of-the-art research facilities. Seminars with high-profile international speakers and regular internal research seminars are organized at the Center. Denmark is often ranked as the happiest nation and Copenhagen is consistently ranked as one of the best cities for living. For more information on working and living in Denmark visit www.ism.ku.dk (International staff mobility) and www.workingconditions.ku.dk.

Terms of salary and employment

Salary, pension, and terms of employment will be in accordance with the Agreement between the Ministry of Finance and AC (Danish Confederation of Professional Associations) or other relevant organisation. Currently, the monthly salary starts around 35.600 DKK (April 2022-level) approx. 4,780 EUR, plus 17.1 % in pension contribution. Depending on qualifications, a supplement may be negotiated.

The Danish Ministry of Finance and the Danish Confederation of Professional Associations (AC) have agreed on a protocol that makes it possible for all international researchers employed by the University to achieve a pension exemption, where the pension can be paid out as salary. For more information about the different pension schemes www.ism.ku.dk/onarrival/pension/

The position is covered by the Job Structure for Academic Staff at Universities 2020.

Duration: The duration of the full-time (37 working hours per week) position is 2 years. Expected starting date 15 September 2022.

Application procedure

Your online application must be submitted in English by clicking ‘Apply now’ below. Furthermore, your application must include the following documents/attachments – all in PDF format:

1. Cover letter

2. CV incl. education, work/research experience, language skills and other skills relevant for the position.

3. A certified/signed copy of a) PhD certificate and b) Master of Science certificate. If the PhD is not completed, a written statement from the supervisor will do. Also, if the degree is not yet awarded, it is sufficient to mention in the cover letter when the applicant expects to submit the thesis, and/or receive the qualifying degree

4. Names and contact details for 2-3 referees

Deadline for applications: 14 July 2022, 23.59pm CET

We reserve the right not to consider material received after the deadline, and not to consider applications that do not live up to the above-mentioned requirements.

The further process

After the expiry of the application deadline, the authorized recruitment manager selects applicants for assessment on the advice of the Appointments Committee. All applicants are then immediately notified whether their application has been passed for assessment by an expert assessment committee. Selected applicants are notified of the composition of the committee and each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself.

You can read about the recruitment process at www.employment.ku.dk .

The applicant will be assessed according to the Ministerial Order no. 242 of 13 March 2012 on the Appointment of Academic Staff at Universities.

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