挪威奥斯陆大学医院2022年招聘博士后职位（儿童癌症研究）

Postdoctoral Research Fellow in Childhood Cancer Research

Institute for Cancer Research, Section for Tumor Biology

We have available a position as Postdoctoral Research Fellow for a fixed term of three years on a project financed by The Norwegian Childhood Cancer Society concerning research on the children cancer rhabdomyosarcoma.

The position is available at the Institute for Cancer Research. The institute hosts core facilities for multiparameter flow cytometery, next generation sequencing, imaging and bioinformatics. The Comprehensive Cancer Center (CCC) of Oslo University Hospital (OUH) at The Norwegian Radium Hospital, is one of the largest Cancer Centers in Europe.

The project is led by Professor Jørgen Wesche who is leader of the "Molecular Biology of Sarcomas” group at the Institute for Cancer Research. The goal of the group is to develop novel opportunities for precision medicine in cancer treatment.

The group is member of a Norwegian Centre of Excellence, Centre for Cancer Cell Reprogramming (CanCell). The group makes extensive use of advanced molecular cell biology methods, proteomics and light microscopy and are developing a platform for CRISPR screening. Home page: https://www.ous-research.no/wesche

Oslo University Hospital is a workplace with great diversity. We believe this is absolutely crucial to solving the tasks required of us. We therefore want this diversity to be reflected among the applicants for our positions and encourage everyone to apply regardless of who you are and what background you have.

Job description

Precision medicine is the new paradigm of modern cancer treatment and gives hope to an increasing number of cancer patients. Unfortunately, childhood cancers seem to lag behind this development mainly because they are rare and therefore difficult to study and they have little commercial interest. While rhabdomyosarcoma (RMS) has a high probability for positive treatment outcome, many patients with metastatic disease succumb to their disease and patients with relapse usually have a dismal prognosis. Furthermore, the high positive treatment rates in childhood cancer may be misleading as many paediatric cancer patients suffer from severe side effects later in life. It is therefore clear that new treatment strategies are required to improve the outcome of paediatric cancer patients.

CRISPR based technologies have revolutionized medical research in the last years and have opened up for affordable genetic screens in mammalian cells to investigate functional networks in cancer. We will perform genetic screens in selected rhabdomyosarcoma cell lines of both alveolar and embryonal origin in order to identify relevant targets for precision medicine. A focused library towards drug targets, kinases and phosphatases (2300 targets) will be applied and the functional readout of the screen will be cell viability in order to identify targets that can inhibit the proliferation of RMS cells.

Novel targets from CRISPR screens will be validated by immunohistochemistry on Norwegian RMS patient material from the Norwegian Childhood Cancer Biobank.

Drugs against selected promising candidates will be tested in panels of RMS cell lines. Mouse models will be used to test drugs in vivo. Thus, we will identify novel targets for precision therapy in RMS with the possibility for further clinical testing.

Eligibility and qualifications

Applicants must hold a doctoral degree (PhD) in life sciences or medicine.

Candidates should have qualifications matching the technologies that will be used in the project (see under job description).

Previous experience with CRISPR/Cas9 technology is required.

Experience in cell biology research is an advantage.

Excellent written and oral communication skills in English.

Personal skills

High working capacity

Strong motivation

Excellent teamwork skills

Interest in solving biological problems

Ability to design, plan, interpret original experiments in an independent and innovative manner

We offer

Excellent working conditions

An exciting and stimulating academic environment

Salary in accordance with experience

Attractive welfare benefits and a generous pension agreement

How to apply:

The application must include:

A one-page statement of motivation and research interests

CV (summarizing education, positions and academic work)

List of publications and academic work that the applicant wishes to be considered by the evaluation committee

Transcripts of university diplomas

Names and contact details of 2-3 references (name, relation to candidate, e-mail and phone number)

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