加拿大英属哥伦比亚大学2022年招聘博士后职位（光子生物传感-微流体）

Postdoctoral Fellow, Photonic Biosensing - Microfluidics

Team overview

The global COVID-19 pandemic has illuminated the urgent need for portable, low-cost, sensitive, accurate, and widely available diagnostics. Our interdisciplinary team in biomedical and electrical engineering (Prof. Karen C. Cheung, Prof. Lukas Chrostowski, Prof. SudipShekhar) has developed a silicon photonic biosensor technology that leverages semiconductor manufacturing economies of scale for integration into a mobile-integrated, portable device that brings the quantitative, data-rich diagnostics of laboratory assays to the point-of-need. In these biosensors, specificity is afforded by the detection chemistry with which the sensor surface is functionalized, and the sample containing the analyte to be measured is delivered to the microchip surface using microfluidics. We are looking to grow our team, searching for applicants with experience in biological sample preparation for diagnostics. Applicants need not have experience in photonics or electronics.

Silicon photonic biosensors can detect a range of biomarker targets relevant to conditions including infectious diseases, cardiology, and neurology, and a key advantage of these biosensors over other technologies is the ability to multiplex measurements of several important biomarker analytes on the same chip. Multiplexed measurement of several biomarkers from the same sample is becoming increasingly important for diagnosis of — and patient stratification within — diseases and conditions for which levels of a single biomarker are not sufficient. We have designed devices with up to 16 multiplexed sensors on the same chip and are characterizing functionalization workflows, microfluidic designs, and sensor performance. The next key steps involve functionalizing the individual sensors to detect different biomarkers, and integrating microfluidic sample preparation into our assay development.

The applicant who accepts this position will join our multidisciplinary team working to develop a portable biosensor built from state-of-the-art silicon photonics technology, in collaboration with the UBC startup company Dream Photonics. The applicant will bring experience in microfluidic diagnostics (e.g., using passive microfluidics or digital microfluidics) to our team as we work to design silicon photonics-based diagnostic assays.

Job description

The position is for a post-doctoral researcher who will work closely with the principal investigators of the interdisciplinary silicon photonic biosensor team. This multidisciplinary team consists of Principal Investigators (PIs) Prof. Karen Cheung, Prof. Lukas Chrostowski, and Prof SudipShekhar. Prof Cheung brings microfluidics and biomedical device expertise and oversees microfluidic delivery and assay development. Prof. Chrostowski brings lasers and silicon photonics expertise and oversees photonic device design and laser integration. Prof. Shekhar brings electronics expertise, and oversees the readout, detection, and signal processing electronics. Under direction of the PIs and in collaboration with our team of postdoctoral fellows, graduate, and undergraduate students, this new postdoctoral appointment will focus on designing a portable, self-contained next-generation microfluidic system that does not require external pumps or valves to provide controlled flow during the diagnostic assay. The successful applicant will also work closely with the leadership team to define and manage project objectives, mentor graduate and undergraduate students, and aid in project management of our interdisciplinary team.

Candidates must have a PhD in Biomedical Engineering, Chemical and Biological Engineering, Biochemistry and Molecular Biology, Electrical Engineering, Physics, Chemistry, or a related discipline. Strong written and oral English communication skills are required. Experience working in interdisciplinary teams is strongly desired. Experience with designing, fabricating, and characterizing microfluidic devices for diagnostics is essential. Experience with biological sample preparation, diagnostic immunoassays, and sensor calibration and analytical validation are strong assets. The applicant should be a self-driven leader and highly motivated researcher.

Work to be performed:

•Benchmarking previously demonstrated classes of microfluidic sample delivery systems against the performance criteria for our silicon photonic biosensor for portable diagnostics at the point of need.

•Designing a next-generation microfluidic sample delivery device for integration with our new biosensor (choosing a microfluidics approach, potentially developing numerical models, pilot designs through rapid prototyping to predict performance, developing a process for fabrication and integration with our existing photonic chip packaging, functionalization, and testing workflows).

•Fabricating and characterizing the performance of the microfluidic sample delivery system.

•Demonstrating the utility of the sample delivery system for select demonstration binding assays, in collaboration with our interdisciplinary team.

•Mentoring and training graduate and undergraduate students.

•Maintaining up-to-date records of project progress and assisting with project management.

•Evaluating the promise and risks of possible sample preparation approaches, and providing feedback to help streamline and optimize these approaches. This will include identification of risks in the path to translation, and helping mitigate these risks.

•Assisting in ensuring that our teams are following Good Laboratory Practice.

Qualifications desired:

•Experience with microfluidic devices, microfabrication, and rapid prototyping for diagnostics applications

•Experience in designing digital microfluidic systems

•Experience with biological sample preparation (e.g., whole blood, urine), preferably for diagnostic assays

•Experience with immunoassay development, ideally using label-free biosensing approaches

•(preferred) Preferred experience with sample preparation using microfluidic devices

•(preferred) Experience with sensor calibration and analytical validation techniques

•(preferred) Knowledge of programming software drivers to control hardware

•(preferred) Fluent with Python, Matlab, and/or similar programming languages

•Interest in project management and team leadership

Minimum requirements:

•Doctorate degree in Biomedical Engineering, Mechanical Engineering, Biochemistry and Molecular Biology, Electrical Engineering, Physics, Chemistry, or a related discipline

•Exceptional candidates without a doctorate degree but with several years of equivalent experience can contact our team to discuss the availability of alternate positions

•Graduating thesis in the field of microfluidic systems or a related topic

To apply:

Please provide the following: a one-page letter of intent which includes a statement of your research interest, a detailed curriculum vitae, a PDF copy or a link to one of your recent and related peer-reviewed publications, and the names of three references.

Complete application packages should be directed to:

Dr. Samantha M. Grist

Email: samantha.grist@ubc.ca

Subject Line: Postdoctoral Fellow, Photonic Biosensing – Microfluidics

This posting is for the UBC Vancouver campus in British Columbia, Canada.

Please refer to reference number NC-56488 during correspondence about this position. Please visit the researcher profile of the supervisor for this position to learn more about their research.

Equity and diversity are essential to academic excellence. An open and diverse community fosters the inclusion of voices that have been underrepresented or discouraged. We encourage applications from members of groups that have been marginalized on any grounds enumerated under the B.C. Human Rights Code, including sex, sexual orientation, gender identity or expression, racialization, disability, political belief, religion, marital or family status, age, and/or status as a First Nation, Metis, Inuit, or Indigenous person.

About UBC

The University of British Columbia is a global centre for research and teaching, consistently ranked among the top 20 public universities in the world. Since 1915, UBC’s entrepreneurial spirit has embraced innovation and challenged the status quo. UBC encourages its students, staff and faculty to challenge convention, lead discovery and explore new ways of learning. At UBC, bold thinking is given a place to develop into ideas that can change the world.

Postdoctoral Fellows at UBC Vancouver

UBC is home to over 900 postdocs spanning all faculties and units across two campuses and a variety of affiliated hospitals, research centres, and sites, providing unparalleled opportunities to learn, discover and contribute in one’s own way. UBC’s Postdoctoral Fellows Office (PDFO) is committed to supporting the lives and career aspirations of our Postdocs, with the goal of enriching their experience at UBC and preparing them for the future. In addition to providing support and advocacy for all postdocs, the PDFO is dedicated to providing professional development opportunities that foster the development of soft skills needed in today’s professional environments, helping them secure future careers in their chosen fields.

About UBC’s Faculty of Applied Science

The Faculty of Applied Science comprises a unique constellation of disciplines – including the Schools of Architecture and Landscape Architecture, Community and Regional Planning and Nursing, as well as all engineering activities at both the Vancouver and Okanagan campuses. Our work and the professional disciplines we represent span the entire human-centred built environment and innovation at all scales – from nanoscale electronic devices that power communications to the design of entire cities.

There has never been a more urgent time for our professions – as planners, architects, nurses and engineers – to come together to build upon our existing strengths and ambitions to ensure a thriving society, to make real impact locally and globally.

With a community of over 300 full-time faculty members and more than 8,600 students across our undergraduate and graduate programs, we shape the leaders and professions that shape the world.

About Vancouver

Vancouver is a dynamic, cosmopolitan and progressive city, consistently ranked as one of the top cities to live in the world. Canada’s third largest city has it all: sea, parks, mountains, beaches, and four seasons per year, including beautiful summers and mild, wet winters with snow in the mountains. It’s the perfect backdrop to your academic research.

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