美国系统生物学研究所(ISB)2022年招聘博士后职位（癌症生物学和转化癌症研究）

Institute for Systems Biology

The Wei Lab at the Institute for Systems Biology (ISB) is seeking highly-motivated postdoctoral candidates in the areas of cancer biology and translational cancer research. The Wei Lab works in the highly cross-disciplinary field of molecular and cellular analysis, tumor epigenetics, and systems biomedicine. We develop and implement innovative single-cell/spatial multi-omics technologies with novel computational approaches to investigate the cutting-edge cancer biology questions with a balance between discovery and clinical translation. We are particularly interested in (1) the cause and consequence of tumor heterogeneity and the intricate cell-cell interactions in the tumor microenvironment for advancing cancer treatment; (2) tumor epigenetic plasticity/dysregulation and its contribution to the treatment-induced adaptive therapy resistance and adaptive mutagenesis; (3) liquid biopsy-based rare cell analysis for predictive cancer diagnostics and immunotherapy. The Wei lab is currently a part of the NIH-funded Cancer Systems Biology Consortium (CSBC), NIH-funded Physical Sciences in Oncology Network (PS-ON), and NIH-funded Innovative Molecular Analysis Technologies (IMAT) Program. Please visit https://wei.systemsbiology.org for more information about the lab.

Candidates should have a Ph.D. in Biology, Computational Biology or Bioinformatics, Biological or Biomedical Engineering, Chemistry, or other related areas. They should have demonstrated the ability or potential to conduct interdisciplinary research with good communication skills and a strong publication record. Candidates with research experience in multi-omics/single-cell data analysis, machine-learning, and computational/systems biology are strongly preferred.

Exceptional candidates for this position may be nominated for the Lee Hood Systems Fellowship (https://isbscience.org/careers/postdocs/hood-fellows/) with an annual stipend of $95,000 over 2-3 years. These nominations are presented by the supporting Faculty member to the entire Faculty for approval. The postdoc candidate will be invited to submit additional information if he/she is nominated.

Interested applicants should submit their curriculum vitae and 1-page cover letter for a brief description of research interest through the online application portal and email a copy of their CV to wwei@systemsbiology.org

About the Institute for Systems Biology (https://isbscience.org)

ISB is a collaborative and cross-disciplinary non-profit biomedical research institute based in Seattle WA, and focuses on some of the most pressing issues in human health, including brain health, cancer, sepsis, and aging, as well as many chronic and infectious diseases. ISB currently hosts 14 research groups with expertise ranging across genetics, microbial genetics, complex molecular machines, macromolecular complexes, gene regulatory networks, immunology, molecular and cell biology, cancer biology, genomics, proteomics, protein chemistry, computational biology, and biotechnology. Unlike in traditional academic departments, our faculty are cross-disciplinary and work collaboratively toward a common vision. This cross-disciplinary approach enables us to take on big, complex problems.

ISB was created by genomics pioneer Dr. Leroy Hood in 2000 as the first-of-its-kind institute dedicated to systems biology. ISB is in the top ranks of scientific institutions worldwide. In 2012, the SCImago ranked ISB 4th worldwide on its Excellence Rate scale. ISB strives for a culture of academic excellence and champions sound scientific research that has real-world translational impact. ISB faculty members have launched several successful companies, including: Cytopeia (acquired by BD in 2008), Integrated Diagnostics, Macrogenics, NanoString Technologies, PACT Pharma, Isoplexis, Sofie Biosciences, and Accelerator Corporation. ISB is an affiliate of Providence St. Joseph Health, one of the largest not-for-profit health care systems in the United States.

ISB is an EOE (M/F/minority/veteran/disability status).

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