意大利人类技术中心基金会2022年招聘博士后职位（结构生物学）

Fondazione Human Technopole

Milan, Italy

Postdoc Coscia Group

https://www.nature.com/naturecareers/job/postdoc-coscia-group-fondazione-human-technopole-765517

APPLICATION CLOSING DATE: November 25th, 2022

Human Technopole (HT) is a new interdisciplinary life science research institute, created and supported by the Italian Government, with the aim of developing innovative strategies to improve human health. HT is composed of five Centres: Computational Biology, Structural Biology, Genomics, Neurogenomics and Health Data Science. The Centres work together to enable interdisciplinary research and to create an open, collaborative environment that will help promote life science research both nationally and internationally.

Open PostDoctoral position at Human Technopole in Francesca Coscia’s group to investigate the molecular mechanisms of thyroid function and disease, by combining electron microscopy (Cryo-EM), biophysics and biochemistry. The research pursued by the successful PostDoctoral candidate is part of the “THYROMOL” project, funded by the European Research Council: https://erc.europa.eu/projects-figures/stories/erc-starting-grants-2021. Please get in touch at francesca.coscia@fht.org for further details.

The position offers a competitive salary and benefits in the vibrant, international scientific environment of Human technopole within the Structural Biology Research Centre, with access to state-of-the-art facilities, like the cryo-EM facility, the Light Microscopy facility, and advanced cell culture facilities, biophysics facilities.

Key tasks and responsibilities:

We are looking for a highly motivated, independent and creative structural biologist to study the impact of protein trafficking on thyroid hormone regulation (with a focus on membrane and extracellular proteins). The postdoctoral fellow will use a combination of high-resolution structural determination (mainly cryo-EM) and biochemical/biophysical techniques to study the structure and mechanism of action of multiple protein complexes. The Postdoc will be part of a multidisciplinary environment and international environment, with the opportunity to learn new methods and be highly supported in developing his/her scientific career.

Job requirements

Essentials:

◦PhD and Track record in protein structure determination or Structural Biology (with a focus on cryo-EM).

◦Required technical skills: proficiency in cloning and protein construct design, protein expression and purification, macromolecular complexes, cryo-EM sample preparation and data collection and analysis.

Additional:

◦Highly desirable technical skills: experience with membrane proteins and glycoproteins. Integration of structural data with proteomics and bioinformatics.

Required personal skills

◦Fluency in English – HT is an international research institute;

◦Ability to manage competing priorities in a fast-paced environment and to work independently;

◦Ability and interest to learn or develop new methodologies;

◦Strong interpersonal skills demonstrated with a proven ability to effectively interact and collaborate with others as part of a team;

◦Ability to build trust through operating with transparency and creating an open and positive environment;

◦Ability to work in a multi-cultural, multi-ethnic environment with sensitivity and respect for diversity.

Application Instructions

Please apply by sending a CV and a up to 2 pages of detailed motivation letter in English only through the dedicated area below (Apply now) and the name and contact details of at least 2 potential referees.

Additional Information:

HT offers a highly collaborative, international culture to foster top quality, interdisciplinary research by promoting a vibrant environment consisting of independent research groups with access to outstanding graduate students, postdoctoral fellows and core facilities.

HT is an inclusive employer that fosters diversity and engages systematically to ensure that equal employment opportunities are provided without regard to age, race, creed, religion, sex, disability, medical condition, sexual orientation, gender identity or expression, national or ethnic origin or any other legally recognized status entitled to protection under applicable laws. HT offers attractive conditions and benefits appropriate to a leading, internationally competitive, research organisation that promotes a collegial and open atmosphere.

Please note that researchers coming to Italy for the first time, or returning after residing abroad, may benefit from very attractive income tax reductions.

Number of positions offered: 1

Contract offered: CCNL Chimico Farmaceutico, Employee level, contract duration corresponding to the duration of the grant.

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