法国国家科学研究中心(CNRS)2022年招聘博士后（LLPS结构分析）

法国国家科学研究中心（法文：Centre national de la recherche scientifique），简称“CNRS”，成立于1939年10月19日，隶属于法国高等教育和研究部，是法国最大的政府研究机构，也是欧洲最大的基础科学研究机构，同时也是世界顶尖的科学研究机构之一。它的使命是探索生命世界、物质、宇宙和人类社会的运作。CNRS因其在科学领域的卓越贡献而在国际上享有盛誉，被认为是世界科学技术发展的“风向标”。在2020自然指数排名中，CNRS名列世界第4。

Post-Doctoral Position On Llps Structural Analysis

Universities and Institutes of France

Organisation/Company: CNRS

Research Field: Biological sciences › Biological engineering Chemistry › Biochemistry Physics › Biophysics

Researcher Profile: Recognised Researcher (R2)

Application Deadline: 08/12/2022 23:59 - Europe/Brussels

Location: France › MONTPELLIER

Type Of Contract: Temporary

Job Status: Full-time

Hours Per Week: 35

Offer Starting Date: 01/02/2023

The project aims at analyzing the formation of LLPS condensates of TopBP1 in vitro and/or in cellulo. TopBP1 (Topoisomerase IIß-binding protein) is a hub protein in human cells that functions at the crossroad of multiple vital cellular processes and assembles nuclear condensates to switch on ATR signaling (see ref.4).

Our group at the Center for Structural Biology (CBS) at the University of Montpellier (South of France) offers one open Postdoc position (18 months) to work on lipid-lipid phase separation (LLPS), a new paradigm in cell compartmentalization, using atomic force microscopy (AFM) including high- speed modality (see ref.1) and correlative AFM-fluorescence microscopy (see ref.2-3).

We are an international team at an interdisciplinary research center with excellent in-house access to state-of-the-art biophysics infrastructure and biochemistry and cell culture facilities. Moreover, several groups at the CBS are working on LLPS, which fosters creativity and collaborations. The research of PE Milhiet's group focuses on the development and use of advanced microscopies (AFM and single molecule fluorescence microscopy) to decipher the molecular mechanisms associated to the organization and remodeling of biological membranes. Our team is pluridisciplinary and counts 15 people including 8 permanent researchers. CBS is an Institute dedicated to research at the forefront of structural biology, biophysics and Bioengineering. It also proposes facilities in these fields. Montpellier is a stunning city on the French Riviera with a significant international research community.

Eligibility criteria

The project is highly interdisciplinary, at the interface of biophysics, cell biology and biochemistry. Therefore, successful applicants are expected to have training and research experience in physics/biophysics, especially advanced skills in AFM. Previous experience in fluorescence imaging (confocal/TIRF/Super Resolution/FLIM), Optics as well as biochemistry, cell biology and computation (e.g. Python) skills will be positively considered. The candidates should have a solid publication record (at least one first author paper). Applicants are expected to have defended their PhD thesis within the last 2 years (< 2 years postdoctoral experience).

Additional comments

References 1) Nasrallah H. et al. J MolBiol 1886:45, 2019. 2) A. Vial et al. Nanoscale, 13(29):12484, 2021. 3) T. Fernandes et al. Scientific Reports, 10(1):7098, 2020. 4) Frattini C et al. Mol Cell. 81(6):1231, 2021.

For more information: "Integrative Biophysics of Membrane" group https: // integrativebiophysicsofmembranes.wordpress.com/ https: // twitter.com/MembranesBiophy

Web site for additional job details

https: // emploi.cnrs.fr/Offres/CDD/UMR5048-FLOLEP-044/Default.aspx

Required Research Experiences

RESEARCH FIELD

Chemistry › Biochemistry

YEARS OF RESEARCH EXPERIENCE

1 - 4

RESEARCH FIELD

Physics › Biophysics

YEARS OF RESEARCH EXPERIENCE

1 - 4

RESEARCH FIELD

Biological sciences › Biological engineering

YEARS OF RESEARCH EXPERIENCE

1 - 4

Offer Requirements

REQUIRED EDUCATION LEVEL

Chemistry: PhD or equivalent

Physics: PhD or equivalent

Biological sciences: PhD or equivalent

REQUIRED LANGUAGES

FRENCH: Basic

Contact Information

Organisation/Company: CNRS

Department: Centre de biologiestructurale

Organisation Type: Public Research Institution

Website: https:// www. cbs.cnrs.fr/

Country: France

City: MONTPELLIER

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